Objective Diabetes Mellitus is considered a bihormonal disorder that involves insulin resistance and insulin deficiency as well as relative or absolute high levels of glucagon. Recently, a strong association has been found between disturbances in circadian rhythms and metabolic disorders such as Diabetes Mellitus and Obesity. In this proposal we will use in vitro techniques to knockdown several clock genes in mouse pancreatic islets, MIN6 and alpha-TC1-9 cell lines to establish the role of clock genes in insulin and glucagon secretion. We will examine the circadian regulation in type 2 diabetes in db/db mice to determine whether disturbances in insulin and glucagon secretion are due to disregulation of circadian rhythm in the pancreas. We will also examine the effect of nutrients in the expression pattern of clock genes by performing in vivo studies in mice. Thus, the overall aim of this proposal is to determine whether clock genes can regulate the secretion of insulin and glucagon and whether pancreatic circadian clock can be involved in the irregular secretion of these hormones in Diabetes. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesmedical and health scienceshealth sciencesnutritionobesity Keywords circadian rhythm clock genes diabetes glucagon secretion insulin secretion Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development" Call for proposal FP7-PEOPLE-IEF-2008 See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE EU contribution € 155 236,08 Address AVENIDA DE LA UNIVERSIDAD S-N 03202 Elche Spain See on map Region Este Comunitat Valenciana Alicante/Alacant Activity type Higher or Secondary Education Establishments Administrative Contact Ivan Quesada (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
