Objectif The purpose of this research project is the development of preclinical anti-cancer drug candidates able to fight hypoxic solid tumours, which are normally resistant to chemotherapy and radiotherapy. Highly invasive tumour cells are characterized by a metabolic switch, known as the Warburg effect, from “normal” oxidative phosphorylation to an increased anaerobic glycolysis. This ensures a sufficient energy supply from glucose, even in hypoxic environments. One of the key enzymes involved in anaerobic glycolisis, the muscle isoform of lactate dehydrogenase (LDH5), has been recently shown to be overexpressed by metastatic cancer cells, and has been linked to the vitality of tumours in hypoxia. This enzyme may be considered as a valid target for new anticancer agents, since its inhibition would lead to a cut in cancer energy supply, thus reducing its metastatic and invasive potential. A validation of LDH5 as a safe target derives from the observation that in humans, hereditary LDH5 deficiency causes a certain level of myopathy only after intense anaerobic exercise, whereas it does not provoke any symptoms under ordinary circumstances. This project will support a qualified international researcher in the management of a research line including molecular design and synthesis of a series of new compounds, as well as in the participation in the biological evaluation of their properties. Each step of his formation will be adequately followed by additional specialized trainers. The host institution has already identified a suitable structural scaffold, based on N-hydroxyheterocycles, which has furnished some preliminary LDH5 inhibitors, comparable to those observed with the few examples known in literature. This scaffold constitutes the basis for the development of a large series of analogues, and thus it increases the chances of finding highly active new LDH5 inhibitors, which will constitute pre-clinical candidates for the treatment of metastatic cancer. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Mots‑clés Anaerobic glycolisis Anticancer Catalysis Click chemistry Cross coupling Enzymology Hydroxyheterocycle Hypoxia Lactate dehydrogenase Medicinal Chemistry Metabolism Organic Chemistry Synthesis Warburg Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-IIF-2008 - Marie Curie Action: "International Incoming Fellowships" Appel à propositions FP7-PEOPLE-IIF-2008 Voir d’autres projets de cet appel Régime de financement MC-IIF - International Incoming Fellowships (IIF) Coordinateur UNIVERSITA DI PISA Contribution de l’UE € 173 825,86 Adresse LUNGARNO PACINOTTI 43/44 56126 Pisa Italie Voir sur la carte Région Centro (IT) Toscana Pisa Type d’activité Higher or Secondary Education Establishments Contact administratif Francesca Lombardi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée