Objectif Fluorinated oxygen- or nitrogen-containing heterocycles (lactones, lactams, pyrrolidines and tetrahydrofurans) are important compounds with application in the pharmaceutical and agrochemical industry or as performance compounds in material science. Enantioenriched F-heterocycles with the fluorine substituent on a stereogenic centre are of particular interest but are not easy to access using known protocols. The aim of this proposal is to develop an asymmetric route (including a catalytic variant) to fluorinated heterocycles from prochiral starting materials relying on a fluorocyclisation as the key step. The project builds on literature and data from our laboratory showing that activated and allylsilanes are amenable to fluorocyclisation. Two approaches will be considered to access enantioenriched fluorocyclised heterocycles, based on the use of both novel chiral N-F reagents and well-documented fluorinated cinchona alkaloid derivatives. Champ scientifique natural scienceschemical sciencesinorganic chemistryhalogens Mots‑clés Organic chemistry Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development" Appel à propositions FP7-PEOPLE-IEF-2008 Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Contribution de l’UE € 171 867,63 Adresse WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Royaume-Uni Voir sur la carte Région South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Type d’activité Higher or Secondary Education Establishments Contact administratif Linda Pialek (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
