Asymmetric Fluorocyclisations

Projektinformationen

FLUCYC

ID Finanzhilfevereinbarung: 235510

Projekt abgeschlossen

Startdatum 1 Mai 2009

Enddatum 30 April 2011

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 171 867,63

EU-Beitrag € 171 867,63

Koordiniert durch

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

Ziel

Fluorinated oxygen- or nitrogen-containing heterocycles (lactones, lactams, pyrrolidines and tetrahydrofurans) are important compounds with application in the pharmaceutical and agrochemical industry or as performance compounds in material science. Enantioenriched F-heterocycles with the fluorine substituent on a stereogenic centre are of particular interest but are not easy to access using known protocols. The aim of this proposal is to develop an asymmetric route (including a catalytic variant) to fluorinated heterocycles from prochiral starting materials relying on a fluorocyclisation as the key step. The project builds on literature and data from our laboratory showing that activated and allylsilanes are amenable to fluorocyclisation. Two approaches will be considered to access enantioenriched fluorocyclised heterocycles, based on the use of both novel chiral N-F reagents and well-documented fluorinated cinchona alkaloid derivatives.

Wissenschaftliches Gebiet

• natural sciences › chemical sciences › inorganic chemistry › halogens

Schlüsselbegriffe

• Organic
• chemistry

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-IEF-2008
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Kontakt Verwaltung

Linda Pialek (Ms.)

• EU-Beitrag: € 171 867,63
• Adresse: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford ; Vereinigtes Königreich
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten