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Re-Evolution of a Non Ribosomal Protein Synthethase

Ziel

Many peptide-based natural products of therapeutic importance are synthesised by nonribosomal peptide synthetases (NRPSs), large, multifunctional enzymes that operate as molecular assembly lines, by coupling and processing an extending chain of amino acid monomers. They are composed of numerous enzyme domains that carry out the steps of the bio-synthesis and provide an efficient route to natural products that are not easily accessible by synthetic chemistry. An efficient exploitation, however, still requires a much deeper understanding of the molecular basis of activity and specificity in NRPS enzymes. A set of approaches dealing with neutral drift, directed evolution and selective enzyme modification will be carried out on the model system TycA, taking advantage of knowledge and technologies available at the host institution as well as through a number of international collaborations and participation in the training programme of the FP7 network ENEFP (dealing with directed evolution of functional proteins).

Wissenschaftliches Gebiet (EuroSciVoc)

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-IEF-2008
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
EU-Beitrag
€ 171 867,63
Adresse
TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
Vereinigtes Königreich
Region
East of England East Anglia Cambridgeshire CC
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
Keine Daten