Skip to main content

A Clostridal Biology Network to Facilitate European-wide Medical Countermeasures and Commercial Exploitation

Objective

There is an urgent need to better understand the basic biology of Clostridium as a prerequisite for both countering the diseases they cause (C.difficile C.perfringens and C.botulinum) and exploiting their beneficial properties in industry (biofuels by C.acetobutylicum) and medicine (cancer therapy by C.sporogenes). Attainment of this goal is being impeded because: (i) European research efforts are fragmented; (ii) there is no coherence between researchers working on pathogenic species and industrially important strains; (iii) there is a demonstrable (SCF-CT-2005-029958) lack of trained young clostridial researchers; (iv) there is inadequate networking between industry and academia, and; (v) effective exploitation of the amassed clostridial genome data has been precluded by a woeful inadequacy in procedures for gene inactivation. Removal of these impediments cannot be achieved at a national level, but requires the creation of a transnational network of multi-disciplinary experts,active in different scientific sectors. The technical hurdle to progress has now been solved by partner 1, who has developed a highly effective andreproducible gene knock-out system. The remaining hurdles will be overcome by bringing together a multidisciplinary team of research expertise from 7 different EU states drawn from Academia (5), Government (3) and different sectors of Industry (3). A principal focus will be to address the deficiency in critical mass by providing young researchers with world class, state-of-the-art, multidisciplinary training in leading scientific and biotechnological skills that have relevance to medical countermeasures against pathogens and the exploitation of non-pathogens in industrial processes and disease intervention. These measures will establish Europe as a ‘Centre of Excellence’ for clostridial research, propelling the community to the forefront of the field, eclipsing the efforts of the rest of the world, and in particular the USA and Japan.

Call for proposal

FP7-PEOPLE-ITN-2008
See other projects for this call

Coordinator

THE UNIVERSITY OF NOTTINGHAM
Address
University Park
NG7 2RD Nottingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 534 256,80
Administrative Contact
Paul Cartledge (Mr.)

Participants (12)

THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 444 925,65
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enda Clarke (Dr.)
UNIVERSITAET ROSTOCK
Germany
EU contribution
€ 428 796,63
Address
Universitatsplatz 1
18055 Rostock
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ursula Kessler (Ms.)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 428 796,63
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Ronchetti (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 453 389,92
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katariina Vainio-Mattila (Ms.)
ZAVOD ZA ZDRAVSTVENO VARSTVO MARIBOR
Slovenia
EU contribution
€ 359 073,43
Address
Prvomajska 1 1
2000 Maribor
Activity type
Research Organisations
Administrative Contact
Melita Kores (Ms.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 428 903,81
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 437 562,92
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Beatrice Saint Cricq (Ms.)
METABOLIC EXPLORER SA
France
EU contribution
€ 430 416,47
Address
Biopole Clermont Limagne
63360 Saint Beauzire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul Michalet (Mr.)
GLAXOSMITHKLINE VACCINES SRL
Italy
EU contribution
€ 424 908,42
Address
Via Fiorentina 1
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gulli Francesco (Dr.)
Phico Therapeutics Ltd

Participation ended

United Kingdom
Address
Babraham Research Campus
CB22 3AT Babraham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heather Fairhead (Dr.)
UNILEVER U.K. CENTRAL RESOURCES LIMITED
United Kingdom
EU contribution
€ 440 760,32
Address
Unilever House, Victoria Embankment 100
EC4Y 0DY London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Mcclure (Dr.)
INTERVET INTERNATIONAL BV

Participation ended

Netherlands
Address
Wim De Korverstraat 35
5831 AN Boxmeer
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mark Van Heumen (Mr.)