Objective Chemical Biology is a new, supradisciplinary field that unites the classically separate disciplines of Chemistry and Biology. This network is centred around understanding the central biological process of phosphate transfer and combines leading experts in synthetic chemistry, enzyme model building, kinetic analysis, protein chemistry and directed evolution in a concerted effort to gain a quantitative understanding of transition states that are key to understanding how biological systems can achieve phosphate transfer with unrivalled efficiency. The quantitative language (i.e. kinetic and molecular recognition studies) used to describe and improve natural enzymes unites all participants and provides the theme for our training programme on analysis of phosphate transfer catalysis. Training in this area is highly interdisciplinary in nature requiring a joint effort of chemists and biologists centred around mechanistic thinking, which is at the core of this proposal. Ultimately our understanding of this central bioreaction should lead to useful applications on the long term, e.g. as artificial nucleases, with potential roles in gene regulation, if efficient catalysis can be combined with selective recognition. This proposal is part of a long-term strategy aimed at developing reagents which act by binding or catalytically (thus as artificial enzymes) to interfere with the expression of specific genes. This can be achieved through selective binding eventually (but not necessarily) followed by cleaving the nucleic acid backbone. Crucially for therapeutic success these reagents have to be deliverd into the cell, which is why delivery issues are also addressed. The incorporation of industrial partners ensures that the full life-span of drug development is covered in this training programme. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural scienceschemical sciencescatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-ITN-2008 - Marie Curie Action: "Networks for Initial Training" Call for proposal FP7-PEOPLE-ITN-2008 See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Address Trinity lane the old schools CB2 1TN Cambridge United Kingdom See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Renata Schaeffer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 320 844,00 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI PADOVA Italy EU contribution € 211 339,00 Address Via 8 febbraio 2 35122 Padova See on map Region Nord-Est Veneto Padova Activity type Higher or Secondary Education Establishments Administrative Contact Armando Gennaro (Prof.) Links Contact the organisation Opens in new window Website Opens in new window KAROLINSKA INSTITUTET Sweden EU contribution € 416 413,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Cecilia Tilly (Ms.) Links Contact the organisation Opens in new window Website Opens in new window TURUN YLIOPISTO Finland EU contribution € 511 120,00 Address Yliopistonmaki 20014 Turku See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Higher or Secondary Education Establishments Administrative Contact Eliisa Sarkilahti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF SHEFFIELD United Kingdom EU contribution € 275 957,00 Address Firth court western bank S10 2TN Sheffield See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Higher or Secondary Education Establishments Administrative Contact Joanne Watson (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITEIT GENT Belgium EU contribution € 199 785,00 Address Sint pietersnieuwstraat 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Administrative Contact Nathalie Vandepitte (Ms.) Links Contact the organisation Opens in new window Website Opens in new window OLIGOMER SCIENCES AB Sweden EU contribution € 193 416,00 Address Sveavagen 18a 182 60 Djursholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Malgorzata Honcharenko (Dr.) Links Contact the organisation Opens in new window WALLAC OY Finland EU contribution € 0,00 Address Mustionkatu 6 20750 Turku See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jari Hovinen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Germany EU contribution € 201 879,00 Address Theodor w adorno platz 1 60323 Frankfurt am main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Mareike Schmitt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window AVARIS AB Sweden EU contribution € 204 298,00 Address C/o karolisnka innovations ab, fogdevreten 2b 17177 Stockholm See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anna Bergan (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
