Skip to main content

Recognition and Cleavage of Biological Phosphates – Molecular Recognition, Mechanism and Biomedical Applications

Objective

Chemical Biology is a new, supradisciplinary field that unites the classically separate disciplines of Chemistry and Biology. This network is centred around understanding the central biological process of phosphate transfer and combines leading experts in synthetic chemistry, enzyme model building, kinetic analysis, protein chemistry and directed evolution in a concerted effort to gain a quantitative understanding of transition states that are key to understanding how biological systems can achieve phosphate transfer with unrivalled efficiency. The quantitative language (i.e. kinetic and molecular recognition studies) used to describe and improve natural enzymes unites all participants and provides the theme for our training programme on analysis of phosphate transfer catalysis. Training in this area is highly interdisciplinary in nature requiring a joint effort of chemists and biologists centred around mechanistic thinking, which is at the core of this proposal. Ultimately our understanding of this central bioreaction should lead to useful applications on the long term, e.g. as artificial nucleases, with potential roles in gene regulation, if efficient catalysis can be combined with selective recognition. This proposal is part of a long-term strategy aimed at developing reagents which act by binding or catalytically (thus as artificial enzymes) to interfere with the expression of specific genes. This can be achieved through selective binding eventually (but not necessarily) followed by cleaving the nucleic acid backbone. Crucially for therapeutic success these reagents have to be deliverd into the cell, which is why delivery issues are also addressed. The incorporation of industrial partners ensures that the full life-span of drug development is covered in this training programme.

Call for proposal

FP7-PEOPLE-ITN-2008
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 320 844
Administrative Contact
Renata Schaeffer (Ms.)

Participants (9)

UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 211 339
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Armando Gennaro (Prof.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 416 413
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cecilia Tilly (Ms.)
TURUN YLIOPISTO
Finland
EU contribution
€ 511 120
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eliisa Sarkilahti (Dr.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 275 957
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joanne Watson (Ms.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 199 785
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Vandepitte (Ms.)
OLIGOMER SCIENCES AB
Sweden
EU contribution
€ 193 416
Address
Sveavagen 18A
182 60 Djursholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Malgorzata Honcharenko (Dr.)
WALLAC OY
Finland
Address
Mustionkatu 6
20750 Turku
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jari Hovinen (Dr.)
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 201 879
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mareike Schmitt (Ms.)
AVARIS AB
Sweden
EU contribution
€ 204 298
Address
C/o Karolisnka Innovations Ab, Fogdevreten 2B
17177 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anna Bergan (Dr.)