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Recognition and Cleavage of Biological Phosphates – Molecular Recognition, Mechanism and Biomedical Applications

Objectif

Chemical Biology is a new, supradisciplinary field that unites the classically separate disciplines of Chemistry and Biology. This network is centred around understanding the central biological process of phosphate transfer and combines leading experts in synthetic chemistry, enzyme model building, kinetic analysis, protein chemistry and directed evolution in a concerted effort to gain a quantitative understanding of transition states that are key to understanding how biological systems can achieve phosphate transfer with unrivalled efficiency. The quantitative language (i.e. kinetic and molecular recognition studies) used to describe and improve natural enzymes unites all participants and provides the theme for our training programme on analysis of phosphate transfer catalysis. Training in this area is highly interdisciplinary in nature requiring a joint effort of chemists and biologists centred around mechanistic thinking, which is at the core of this proposal. Ultimately our understanding of this central bioreaction should lead to useful applications on the long term, e.g. as artificial nucleases, with potential roles in gene regulation, if efficient catalysis can be combined with selective recognition. This proposal is part of a long-term strategy aimed at developing reagents which act by binding or catalytically (thus as artificial enzymes) to interfere with the expression of specific genes. This can be achieved through selective binding eventually (but not necessarily) followed by cleaving the nucleic acid backbone. Crucially for therapeutic success these reagents have to be deliverd into the cell, which is why delivery issues are also addressed. The incorporation of industrial partners ensures that the full life-span of drug development is covered in this training programme.

Champ scientifique

  • /sciences naturelles/sciences biologiques/biochimie/biomolécules/acide nucléique
  • /lettres/langues et littérature/langues - général

Appel à propositions

FP7-PEOPLE-ITN-2008
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Régime de financement

MC-ITN - Networks for Initial Training (ITN)

Coordinateur

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 320 844
Contact administratif
Renata Schaeffer (Ms.)

Participants (9)

UNIVERSITA DEGLI STUDI DI PADOVA
Italie
Contribution de l’UE
€ 211 339
Adresse
Via 8 Febbraio 2
35122 Padova
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Armando Gennaro (Prof.)
KAROLINSKA INSTITUTET
Suède
Contribution de l’UE
€ 416 413
Adresse
Nobels Vag 5
17177 Stockholm
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Cecilia Tilly (Ms.)
TURUN YLIOPISTO
Finlande
Contribution de l’UE
€ 511 120
Adresse
Yliopistonmaki
20014 Turku
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Eliisa Sarkilahti (Dr.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Contribution de l’UE
€ 275 957
Adresse
Firth Court Western Bank
S10 2TN Sheffield
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Joanne Watson (Ms.)
UNIVERSITEIT GENT
Belgique
Contribution de l’UE
€ 199 785
Adresse
Sint Pietersnieuwstraat 25
9000 Gent
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Nathalie Vandepitte (Ms.)
OLIGOMER SCIENCES AB
Suède
Contribution de l’UE
€ 193 416
Adresse
Sveavagen 18A
182 60 Djursholm
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Malgorzata Honcharenko (Dr.)
WALLAC OY
Finlande
Adresse
Mustionkatu 6
20750 Turku
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Jari Hovinen (Dr.)
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Allemagne
Contribution de l’UE
€ 201 879
Adresse
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Mareike Schmitt (Ms.)
AVARIS AB
Suède
Contribution de l’UE
€ 204 298
Adresse
C/o Karolisnka Innovations Ab, Fogdevreten 2B
17177 Stockholm
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Anna Bergan (Dr.)