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Recognition and Cleavage of Biological Phosphates – Molecular Recognition, Mechanism and Biomedical Applications

Obiettivo

Chemical Biology is a new, supradisciplinary field that unites the classically separate disciplines of Chemistry and Biology. This network is centred around understanding the central biological process of phosphate transfer and combines leading experts in synthetic chemistry, enzyme model building, kinetic analysis, protein chemistry and directed evolution in a concerted effort to gain a quantitative understanding of transition states that are key to understanding how biological systems can achieve phosphate transfer with unrivalled efficiency. The quantitative language (i.e. kinetic and molecular recognition studies) used to describe and improve natural enzymes unites all participants and provides the theme for our training programme on analysis of phosphate transfer catalysis. Training in this area is highly interdisciplinary in nature requiring a joint effort of chemists and biologists centred around mechanistic thinking, which is at the core of this proposal. Ultimately our understanding of this central bioreaction should lead to useful applications on the long term, e.g. as artificial nucleases, with potential roles in gene regulation, if efficient catalysis can be combined with selective recognition. This proposal is part of a long-term strategy aimed at developing reagents which act by binding or catalytically (thus as artificial enzymes) to interfere with the expression of specific genes. This can be achieved through selective binding eventually (but not necessarily) followed by cleaving the nucleic acid backbone. Crucially for therapeutic success these reagents have to be deliverd into the cell, which is why delivery issues are also addressed. The incorporation of industrial partners ensures that the full life-span of drug development is covered in this training programme.

Invito a presentare proposte

FP7-PEOPLE-ITN-2008
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Meccanismo di finanziamento

MC-ITN - Networks for Initial Training (ITN)

Coordinatore

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Indirizzo
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 320 844
Contatto amministrativo
Renata Schaeffer (Ms.)

Partecipanti (9)

UNIVERSITA DEGLI STUDI DI PADOVA
Italia
Contributo UE
€ 211 339
Indirizzo
Via 8 Febbraio 2
35122 Padova
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Armando Gennaro (Prof.)
KAROLINSKA INSTITUTET
Svezia
Contributo UE
€ 416 413
Indirizzo
Nobels Vag 5
17177 Stockholm
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Cecilia Tilly (Ms.)
TURUN YLIOPISTO
Finlandia
Contributo UE
€ 511 120
Indirizzo
Yliopistonmaki
20014 Turku
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Eliisa Sarkilahti (Dr.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Contributo UE
€ 275 957
Indirizzo
Firth Court Western Bank
S10 2TN Sheffield
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Joanne Watson (Ms.)
UNIVERSITEIT GENT
Belgio
Contributo UE
€ 199 785
Indirizzo
Sint Pietersnieuwstraat 25
9000 Gent
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Nathalie Vandepitte (Ms.)
OLIGOMER SCIENCES AB
Svezia
Contributo UE
€ 193 416
Indirizzo
Sveavagen 18A
182 60 Djursholm
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Malgorzata Honcharenko (Dr.)
WALLAC OY
Finlandia
Indirizzo
Mustionkatu 6
20750 Turku
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Jari Hovinen (Dr.)
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germania
Contributo UE
€ 201 879
Indirizzo
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Mareike Schmitt (Ms.)
AVARIS AB
Svezia
Contributo UE
€ 204 298
Indirizzo
C/o Karolisnka Innovations Ab, Fogdevreten 2B
17177 Stockholm
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Anna Bergan (Dr.)