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Structural studies of peroxisomal machinery

Objetivo

Peroxisomes are organelles responsible for essential metabolic processes such as fatty acid oxidation. These organelles contain specialized machinery for protein import and membrane protein insertion. These systems have been well characterized at the genetic, cellular and biochemical level and there is a good understanding of the number and identity of the different components and their functional relationships. There is however a lack of structural information about the proteins that are involved in the two machineries, which is reflected in the relatively poor molecular detail of the respective mechanistic models.
The general aim of this proposal is the determination of crystal structures of different proteins and protein complexes from the two systems. These structures will reveal molecular details about the different protein components and will provide new insights about the mechanisms of peroxisomal matrix import and membrane protein insertion.

Ámbito científico (EuroSciVoc)

Palabras clave

Programa(s)

Tema(s)

Convocatoria de propuestas

FP7-PEOPLE-IRG-2008
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MC-IRG - International Re-integration Grants (IRG)

Coordinador

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Aportación de la UE
€ 100 000,00
Dirección
RUA ALFREDO ALLEN 208
4200 135 Porto
Portugal
Región
Continente Norte Área Metropolitana do Porto
Tipo de actividad
Research Organisations
Enlaces
Coste total
Sin datos