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Structural studies of peroxisomal machinery

Obiettivo

Peroxisomes are organelles responsible for essential metabolic processes such as fatty acid oxidation. These organelles contain specialized machinery for protein import and membrane protein insertion. These systems have been well characterized at the genetic, cellular and biochemical level and there is a good understanding of the number and identity of the different components and their functional relationships. There is however a lack of structural information about the proteins that are involved in the two machineries, which is reflected in the relatively poor molecular detail of the respective mechanistic models.
The general aim of this proposal is the determination of crystal structures of different proteins and protein complexes from the two systems. These structures will reveal molecular details about the different protein components and will provide new insights about the mechanisms of peroxisomal matrix import and membrane protein insertion.

Campo scientifico (EuroSciVoc)

Parole chiave

Argomento(i)

Invito a presentare proposte

FP7-PEOPLE-IRG-2008
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Meccanismo di finanziamento

MC-IRG - International Re-integration Grants (IRG)

Coordinatore

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Contributo UE
€ 100 000,00
Indirizzo
RUA ALFREDO ALLEN 208
4200 135 Porto
Portogallo
Regione
Continente Norte Área Metropolitana do Porto
Tipo di attività
Research Organisations
Collegamenti
Costo totale
Nessun dato