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Structural studies of peroxisomal machinery

Ziel

Peroxisomes are organelles responsible for essential metabolic processes such as fatty acid oxidation. These organelles contain specialized machinery for protein import and membrane protein insertion. These systems have been well characterized at the genetic, cellular and biochemical level and there is a good understanding of the number and identity of the different components and their functional relationships. There is however a lack of structural information about the proteins that are involved in the two machineries, which is reflected in the relatively poor molecular detail of the respective mechanistic models.
The general aim of this proposal is the determination of crystal structures of different proteins and protein complexes from the two systems. These structures will reveal molecular details about the different protein components and will provide new insights about the mechanisms of peroxisomal matrix import and membrane protein insertion.

Wissenschaftliches Gebiet (EuroSciVoc)

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-IRG-2008
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IRG - International Re-integration Grants (IRG)

Koordinator

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
EU-Beitrag
€ 100 000,00
Adresse
RUA ALFREDO ALLEN 208
4200 135 Porto
Portugal
Region
Continente Norte Área Metropolitana do Porto
Aktivitätstyp
Research Organisations
Links
Gesamtkosten
Keine Daten