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Collagen scaffolds for bone regeneration: applied biomaterials, bioreactor and stem cell technology

Objective

Regenerative medicine aims to regenerate damaged tissues by developing functional cell, tissue, and organ substitutes to repair, replace or enhance biological function in damaged tissues. The focus of this research programme is to develop bone graft substitute biomaterials and laboratory-engineered bone tissue for implantation in damaged sites. At a simplistic level, biological tissues consist of cells, signalling mechanisms and extracellular matrix. Regenerative medicine/tissue engineering technologies are based on this biological triad and involve the successful interaction between three components: the scaffold that holds the cells together to create the tissues physical form, the cells that create the tissue, and the biological signalling mechanisms (such as growth factors or bioreactors) that direct the cells to express the desired tissue phenotype. The research proposed in this project includes specific projects in all three areas. The programme will be centred on the collagen-based biomaterials developed in the applicant s laboratory and will incorporate cutting edge stem cell technologies, growth factor delivery, gene therapy and bioreactor technology which will translate to in vivo tissue repair. This translational research programme will be divided into four specific themes: (i) development of novel osteoinductive and angiogenic smart scaffolds for bone tissue regeneration, (ii) scaffold and stem cell therapies for bone tissue regeneration, (iii) bone tissue engineering using a flow perfusion bioreactor and (iv) in vivo bone repair using engineered bone and smart scaffolds.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /engineering and technology/industrial biotechnology/biomaterials
  • /engineering and technology/environmental biotechnology/bioremediation/bioreactor
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy

Call for proposal

ERC-2009-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

ROYAL COLLEGE OF SURGEONS IN IRELAND
Address
Saint Stephen's Green 123
2 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 999 530
Principal investigator
Fergal Joseph O'brien (Prof.)
Administrative Contact
Paola Della Porta (Dr.)

Beneficiaries (1)

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
EU contribution
€ 1 999 530
Address
Saint Stephen's Green 123
2 Dublin
Activity type
Higher or Secondary Education Establishments
Principal investigator
Fergal Joseph O'brien (Prof.)
Administrative Contact
Paola Della Porta (Dr.)