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Identification and development of vaccine candidates for Buruli Ulcer Disease

Objective

Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD, the third most common mycobacterial disease in immunocompetent humans after tuberculosis and leprosy, is most endemic in West Africa, but cases have been reported from more than 30 countries. BUD is a mutilating disease leading to severe disability. Treatment with antibiotics is possible but is long-lasting and requires injections, shows treatment failures and drug resistance may occur. A vaccine against M. ulcerans would protect persons at risk in highly endemic areas and could be used as a therapeutic vaccine to shorten duration of treatment and to prevent relapses. The general objective of BuruliVac is to identify and develop novel vaccine candidates suitable for translation into clinical application. This objective will be achieved by a multidisciplinary approach involving among others basic and applied research in immunology, bioinformatics, molecular genetics, tropical medicine, microbiology and clinical bacteriology. As currently no existing vaccine lead candidate is available, the consortium will identify and develop new vaccine candidates of different types, will evaluate them using bioinformatics, applied genomics and proteomics and will subject them to consecutive test systems. For evaluation of vaccine candidates regarding their application in humans, the consortium will also study the immune response and disease immunopathology to define correlates of protection. Essential pre-clinical testing in vitro and in vivo will select a small number of candidates that is amenable to be introduced into clinical studies.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /natural sciences/biological sciences/microbiology/bacteriology
  • /natural sciences/biological sciences/genetics and heredity
  • /medical and health sciences/health sciences/tropical medicine
  • /natural sciences/biological sciences/molecular biology/molecular genetics

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Address
Bernhard Nocht Strasse 74
20359 Hamburg
Germany
Activity type
Research Organisations
EU contribution
€ 438 413
Administrative Contact
Susanne Crohn (Ms.)

Participants (15)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 398 392
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gisela Bretzel (Dr.)
PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
EU contribution
€ 326 130
Address
Nationalestraat 155
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jef Van Lint (Mr.)
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT
Switzerland
EU contribution
€ 465 383
Address
Socinstrasse 57
CH-4002 Basel
Activity type
Research Organisations
Administrative Contact
Stefan Mörgeli (Mr.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 131 570
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Craven (Mr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 120 902
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katinka Mulder (Ms.)
INSTITUT PASTEUR
France
EU contribution
€ 384 592
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
UNIVERSIDADE DO MINHO
Portugal
EU contribution
€ 232 344
Address
Largo Do Paco
4704 553 Braga
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rui Manuel Costa Vieira De Castro (Prof.)
DEUTSCHES LEPRA- UND TUBERKULOSEHILFE EV
Germany
EU contribution
€ 218 306
Address
Mariannhillstrasse 1C
97074 Wurzburg
Activity type
Other
Administrative Contact
Carola Muehleisen (Ms.)
KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY KUMASI
Ghana
EU contribution
€ 368 576
Address
Private Mail Bag, University Post Office
ASH Kumasi
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kwabena Antwi Danso (Prof.)
Ministere de la sante
Benin
EU contribution
€ 143 131
Address
N/a
06 BP 3029 Cotonou
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Affolabi Albert Fatolou (Mr.)
CENTRE NATIONAL HOSPITALIER DE PNEUMO-PHTISIOLOGIE
Benin
EU contribution
€ 142 729
Address
Lazaret Akpakpa
01 Cotonou
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Koissi Pascal Mensah (Mr.)
INSTITUT MEDICAL EVANGELIQUE DE KIMPESE
Democratic Republic of the Congo
EU contribution
€ 257 470
Address
Matadi Road Ime/kimpese Hospital
Kimpese
Activity type
Research Organisations
Administrative Contact
Virginie Basilua Nzuzi (Ms.)
INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE
Belgium
EU contribution
€ 395 420
Address
Rue Juliette Wytsman 14
1050 Bruxelles
Activity type
Research Organisations
Administrative Contact
Hilde Millaire (Ms.)
LIONEX GMBH
Germany
EU contribution
€ 263 225
Address
Salzdahlumer Strasse 196
38126 Braunschweig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mahavir Singh (Prof.)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 313 400
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vera Siegmund (Dr.)