European Commission logo
italiano italiano
CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-06-18

European large-scale functional genomics in the rat for translational research

Obiettivo

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.

The EU FP6 Euratools consortium has been a remarkable success that established significant research collaborations, expertise and infrastructure in the EU, making a major contribution to the rat focus issue of Nature Genetics (Volume 40, May 2008), which featured six papers from the consortium. These successes underpin the current project in which we will use state-of-the-art and emerging large-scale technologies and advanced computation in an expanded multi-disciplinary approach to identify gene networks and genomic mechanisms underlying common diseases. We will use the rat as a model system to identify the major functional pathways underlying human inflammatory, cardiovascular and metabolic, and behavioral disorders.

Our consortium brings together world class investigators who will use next-generation sequencing technologies to generate genomic, transcriptomic and epigenomic datasets. To this, we will add cutting-edge, quantitative metabonomic and proteomic datasets to give significant depth of coverage, at multiple levels, across pathophysiological phenotypes. These datasets will be gathered, annotated and integrated in relational and dynamic models that will be used in comparative analyses to understand human gene function at the level of the molecule, cell, tissue and organism. These studies will lead to new insights into disease mechanisms, through an integrative, cross-disciplinary approach to understanding large-scale functional genomic datasets in rats and humans.

Campo scientifico

Programma(i)

Argomento(i)

Invito a presentare proposte

FP7-HEALTH-2009-two-stage
Vedi altri progetti per questo bando

Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Contributo UE
€ 1 980 000,00
Indirizzo
ROBERT ROSSLE STRASSE 10
13125 Berlin
Germania

Mostra sulla mappa
Regione
Berlin Berlin Berlin
Tipo di attività
Research Organisations
Contatto amministrativo
Norbert Hubner (Prof.)
Collegamenti
Costo totale
Nessun dato

Partecipanti (18)

Condividi questa pagina

Scarica

Ultimo aggiornamento: 29 Maggio 2017

Il mio booklet

Permalink: https://cordis.europa.eu/project/id/241504/it

European Union, 2024