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ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS

Objective

Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experience on cell therapy, logistic and production facilities for adipose derived stromal cells (ASC) and clinical studies focusing on cartilage repair. They have shown that stromal cells have anti-inflammatory and antiapoptosis effets, prevent cells from senescence and protect endogenous cells from oxidative stress. ASC are well described, and the procedure to expand the ASC in GMP clinical grade by one of us has been approved by regulatory authorities. This has prompted us to propose an original and innovative regenerative medicine approach for OA in a four years programme organised around 6 workpackages : · WP 1 ASC biology, cell processing & optimization for chondral protection · WP 2 In vivo validation of chondroprotective effect of ASC · WP 3 Safety, Security & regulatory issues · WP 4 Clinical trial endogenous ASC injected intraarticular in OA · WP 5 Management and Coordination · WP 6 Training and Education ADIPOA project will then lead to the optimisation and standardisation of production procedures. In vivo validation and optimisation shall lead to a phase 1 clinical trial and the design and initiation of a phase 2 controlled study in OA. The ADIPOA Consortium comprises 10 academic and 2 sme participants and gathers researchers and clinicians with expertise in clinical research, chondrocytes and adipose stem cell biology and regenerative medicine. The Sme participation will ensure the dissemination of the project results. The critical mass achieved by the ADIPOA Consortium should enable clinical applications in OA.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
Address
Avenue Du Doyen Gaston Giraud 191
34000 Montpellier
France
Activity type
Other
EU contribution
€ 2 167 455
Administrative Contact
Valérie Handweiler (Ms.)

Participants (11)

NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 477 616
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roger Sweetman (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 548 098
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Armelle Barelli (Dr.)
ISTITUTO ORTOPEDICO RIZZOLI
Italy
EU contribution
€ 769 750
Address
Via Di Barbiano 1/10
40136 Bologna
Activity type
Research Organisations
Administrative Contact
Andrea Rizzi (Dr.)
Laboratoires MABIO International
France
EU contribution
€ 385 700
Address
Du Pont Rompu 96
59203 Tourcoing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dominique Malard (Mr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 636 320
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maarten Van Langen (Mr.)
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
EU contribution
€ 848 150
Address
Sanderring 2
97070 Wuerzburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Gloggengiesser (Mr.)
MRB Forschungszentrum fur Magnet-Resonanz-Bayern e.V.
Germany
EU contribution
€ 693 440
Address
Am Hubland
97074 Wuerzburg
Activity type
Research Organisations
Administrative Contact
Karl-Heinz Hiller (Dr.)
ETABLISSEMENT FRANCAIS DU SANG
France
EU contribution
€ 634 687
Address
Avenue Du Stade De France 20
93210 La Plaine Saint Denis
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
François Destruel (Dr.)
PROCORE LTD
Israel
EU contribution
€ 576 600
Address
Golda Meir 7 Weizmann Science Park 7
70400 Nes Ziona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Avner Yayon (Prof.)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 889 944
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Faber (Dr.)
VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS INOVATYVIOS MEDICINOS CENTRAS
Lithuania
EU contribution
€ 596 712
Address
Zygimantu 9
01102 Vilnius
Activity type
Other
Administrative Contact
Jolanta Dadoniene (Prof.)