Skip to main content

Cutaneous and Mucosal HIV Vaccination

Objective

Despite significant effort over the past decade to design and implement new vaccines strategies against HIV, no one has met its promise to prevent infection and/or to reduce viral load until reaching eradication of the HIV reservoir. To reach this goal, a translational research is critical to propose innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cellular immune responses specific to HIV antigens. Composed by 13 partners from 5 European countries and 2 International Cooperation countries, the CUT’HIVAC consortium gathers knowledge’s and cutting-edge technologies in vaccinology and HIV diseases to raise the challenge of developing a new HIV strategy. The CUT’HIVAC approach is based on innovative transcutaneous and/or mucosal needle-free vaccination methods in a perspective that new vaccine candidates will redirect immune response toward cytotoxic CD8 and mucosal humoral responses. The trust of the project derives from the proof-of-concept that combination of routes of immunization and delivery systems will shape the immune responses towards its protective arms against HIV. Clinical trials will be implemented with last cutting-edge generation of HIV DNA-GTU® candidate applied by transcutaneous, intradermal routes and/or mucosal administration of HIV-envelop protein-based vaccine. Large efforts will be positioned on the new genetic design of HIV antigens and delivery systems for developed and developing countries. These new vaccines will be tested in innovative preclinical approaches with a special highlight on routes of vaccination that will be translated into 2nd round of clinical trials in a perspective that could help to prevent and eradicate HIV. Through its integrative and multidisciplinary approach, CUT’HIVAC will therefore provide the basis for a novel approach in vaccination with a view to wide its application to other infectious diseases such as malaria and tuberculosis.

Field of science

  • /medical and health sciences/health sciences/infectious disease
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
Address
Place Jussieu 4
75252 Paris
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 963 463,30
Administrative Contact
Lucie Salvaudon (Dr.)

Participants (17)

NOVAMEN SAS

Participation ended

France
EU contribution
€ 368 306
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vincent Grosbois (Mr.)
UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 1 270 801
Address
Universitatsstrasse 31
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Blomeyer (Dr.)
FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA
Spain
EU contribution
€ 974 680
Address
Carretera De Canyet
08916 Barcelona
Activity type
Research Organisations
Administrative Contact
Anna Tor (Ms.)
FIT BIOTECH OY
Finland
EU contribution
€ 1 648 460
Address
Biokatu 8
33520 Tampere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Liisa Irmeli Laitinen (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 621 400
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL

Participation ended

United Kingdom
EU contribution
€ 119 326,50
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Craven (Dr.)
Investigaciones Medicas en Salud

Participation ended

Peru
EU contribution
€ 130 899,74
Address
Jose De La Torre Ugarte 166
L 14 Lima
Activity type
Research Organisations
Administrative Contact
Sergio Chavez (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 759 760
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Sandrine Magnetto (Dr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 108 095,64
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Richard Frost (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 96 811,04
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Mihaja Auguste (Ms.)
Instituto Nacional de Saúde
Mozambique
EU contribution
€ 241 334
Address
Avenida Eduardo Mondlane 1008
Maputo
Activity type
Research Organisations
Administrative Contact
Maria Helena Abdul (Ms.)
ACIES Consulting Group SAS
France
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vincent Grosbois (Mr.)
GENEART AG
Germany
EU contribution
€ 109 599
Address
Josef-engert-strasse 9
93053 Regensburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Melanie Meyer (Ms.)
ASOCIACION CIVIL IMPACTA SALUD Y EDUCACION
Peru
EU contribution
€ 282 338
Address
Avenida Almirante Miguel Grau 1010
L04 Lima
Activity type
Research Organisations
Administrative Contact
Jose Joaquin Ojeda Celi (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 2 963 186,32
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
OBJECTIF RECHERCHE VACCIN SIDA
France
EU contribution
€ 30 966,60
Address
Boulevard De L Hopital 47-83
75013 Paris
Activity type
Research Organisations
Administrative Contact
François Lecardonnel (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 239 822,86
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Malgorzata Kielbasa (Ms.)