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Cutaneous and Mucosal HIV Vaccination

Objectif

Despite significant effort over the past decade to design and implement new vaccines strategies against HIV, no one has met its promise to prevent infection and/or to reduce viral load until reaching eradication of the HIV reservoir. To reach this goal, a translational research is critical to propose innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cellular immune responses specific to HIV antigens. Composed by 13 partners from 5 European countries and 2 International Cooperation countries, the CUT’HIVAC consortium gathers knowledge’s and cutting-edge technologies in vaccinology and HIV diseases to raise the challenge of developing a new HIV strategy. The CUT’HIVAC approach is based on innovative transcutaneous and/or mucosal needle-free vaccination methods in a perspective that new vaccine candidates will redirect immune response toward cytotoxic CD8 and mucosal humoral responses. The trust of the project derives from the proof-of-concept that combination of routes of immunization and delivery systems will shape the immune responses towards its protective arms against HIV. Clinical trials will be implemented with last cutting-edge generation of HIV DNA-GTU® candidate applied by transcutaneous, intradermal routes and/or mucosal administration of HIV-envelop protein-based vaccine. Large efforts will be positioned on the new genetic design of HIV antigens and delivery systems for developed and developing countries. These new vaccines will be tested in innovative preclinical approaches with a special highlight on routes of vaccination that will be translated into 2nd round of clinical trials in a perspective that could help to prevent and eradicate HIV. Through its integrative and multidisciplinary approach, CUT’HIVAC will therefore provide the basis for a novel approach in vaccination with a view to wide its application to other infectious diseases such as malaria and tuberculosis.

Appel à propositions

FP7-HEALTH-2009-single-stage
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Coordinateur

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
Adresse
Place Jussieu 4
75252 Paris
France
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 1 963 463,30
Contact administratif
Lucie Salvaudon (Dr.)

Participants (17)

NOVAMEN SAS

Participation terminée

France
Contribution de l’UE
€ 368 306
Adresse
Rue De La République 69
69002 Lyon
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Vincent Grosbois (Mr.)
UNIVERSITAET REGENSBURG
Allemagne
Contribution de l’UE
€ 1 270 801
Adresse
Universitatsstrasse 31
93053 Regensburg
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Christian Blomeyer (Dr.)
FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA
Espagne
Contribution de l’UE
€ 974 680
Adresse
Carretera De Canyet
08916 Barcelona
Type d’activité
Research Organisations
Contact administratif
Anna Tor (Ms.)
FIT BIOTECH OY
Finlande
Contribution de l’UE
€ 1 648 460
Adresse
Biokatu 8
33520 Tampere
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Liisa Irmeli Laitinen (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Allemagne
Contribution de l’UE
€ 621 400
Adresse
Chariteplatz 1
10117 Berlin
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Eveline Fräßdorf (Ms.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL

Participation terminée

United Kingdom
Contribution de l’UE
€ 119 326,50
Adresse
Cranmer Terrace
SW17 0RE London
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Paul Craven (Dr.)
Investigaciones Medicas en Salud

Participation terminée

Pérou
Contribution de l’UE
€ 130 899,74
Adresse
Jose De La Torre Ugarte 166
L 14 Lima
Type d’activité
Research Organisations
Contact administratif
Sergio Chavez (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Contribution de l’UE
€ 759 760
Adresse
Rue Michel Ange 3
75794 Paris
Type d’activité
Other
Contact administratif
Sandrine Magnetto (Dr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
Contribution de l’UE
€ 108 095,64
Adresse
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Type d’activité
Research Organisations
Contact administratif
Richard Frost (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Contribution de l’UE
€ 96 811,04
Adresse
Rue De Tolbiac 101
75654 Paris
Type d’activité
Research Organisations
Contact administratif
Mihaja Auguste (Ms.)
Instituto Nacional de Saúde
Mozambique
Contribution de l’UE
€ 241 334
Adresse
Avenida Eduardo Mondlane 1008
Maputo
Type d’activité
Research Organisations
Contact administratif
Maria Helena Abdul (Ms.)
ACIES Consulting Group SAS
France
Adresse
Rue De La République 69
69002 Lyon
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Vincent Grosbois (Mr.)
GENEART AG
Allemagne
Contribution de l’UE
€ 109 599
Adresse
Josef-engert-strasse 9
93053 Regensburg
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Melanie Meyer (Ms.)
ASOCIACION CIVIL IMPACTA SALUD Y EDUCACION
Pérou
Contribution de l’UE
€ 282 338
Adresse
Avenida Almirante Miguel Grau 1010
L04 Lima
Type d’activité
Research Organisations
Contact administratif
Jose Joaquin Ojeda Celi (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Contribution de l’UE
€ 2 963 186,32
Adresse
South Kensington Campus Exhibition Road
SW7 2AZ London
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Tatjana Palalic (Ms.)
OBJECTIF RECHERCHE VACCIN SIDA
France
Contribution de l’UE
€ 30 966,60
Adresse
Boulevard De L Hopital 47-83
75013 Paris
Type d’activité
Research Organisations
Contact administratif
François Lecardonnel (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Contribution de l’UE
€ 239 822,86
Adresse
Gower Street
WC1E 6BT London
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Malgorzata Kielbasa (Ms.)