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Cutaneous and Mucosal HIV Vaccination

Objetivo

Despite significant effort over the past decade to design and implement new vaccines strategies against HIV, no one has met its promise to prevent infection and/or to reduce viral load until reaching eradication of the HIV reservoir. To reach this goal, a translational research is critical to propose innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cellular immune responses specific to HIV antigens. Composed by 13 partners from 5 European countries and 2 International Cooperation countries, the CUT’HIVAC consortium gathers knowledge’s and cutting-edge technologies in vaccinology and HIV diseases to raise the challenge of developing a new HIV strategy. The CUT’HIVAC approach is based on innovative transcutaneous and/or mucosal needle-free vaccination methods in a perspective that new vaccine candidates will redirect immune response toward cytotoxic CD8 and mucosal humoral responses. The trust of the project derives from the proof-of-concept that combination of routes of immunization and delivery systems will shape the immune responses towards its protective arms against HIV. Clinical trials will be implemented with last cutting-edge generation of HIV DNA-GTU® candidate applied by transcutaneous, intradermal routes and/or mucosal administration of HIV-envelop protein-based vaccine. Large efforts will be positioned on the new genetic design of HIV antigens and delivery systems for developed and developing countries. These new vaccines will be tested in innovative preclinical approaches with a special highlight on routes of vaccination that will be translated into 2nd round of clinical trials in a perspective that could help to prevent and eradicate HIV. Through its integrative and multidisciplinary approach, CUT’HIVAC will therefore provide the basis for a novel approach in vaccination with a view to wide its application to other infectious diseases such as malaria and tuberculosis.

Convocatoria de propuestas

FP7-HEALTH-2009-single-stage
Consulte otros proyectos de esta convocatoria

Régimen de financiación

CP-IP - Large-scale integrating project

Coordinador

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
Dirección
Place Jussieu 4
75252 Paris
Francia
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 963 463,30
Contacto administrativo
Lucie Salvaudon (Dr.)

Participantes (17)

NOVAMEN SAS

La participación finalizó

Francia
Aportación de la UE
€ 368 306
Dirección
Rue De La République 69
69002 Lyon
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Vincent Grosbois (Mr.)
UNIVERSITAET REGENSBURG
Alemania
Aportación de la UE
€ 1 270 801
Dirección
Universitatsstrasse 31
93053 Regensburg
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Christian Blomeyer (Dr.)
FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA
España
Aportación de la UE
€ 974 680
Dirección
Carretera De Canyet
08916 Barcelona
Tipo de actividad
Research Organisations
Contacto administrativo
Anna Tor (Ms.)
FIT BIOTECH OY
Finlandia
Aportación de la UE
€ 1 648 460
Dirección
Biokatu 8
33520 Tampere
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Liisa Irmeli Laitinen (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Alemania
Aportación de la UE
€ 621 400
Dirección
Chariteplatz 1
10117 Berlin
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Eveline Fräßdorf (Ms.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL

La participación finalizó

United Kingdom
Aportación de la UE
€ 119 326,50
Dirección
Cranmer Terrace
SW17 0RE London
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Paul Craven (Dr.)
Investigaciones Medicas en Salud

La participación finalizó

Perú
Aportación de la UE
€ 130 899,74
Dirección
Jose De La Torre Ugarte 166
L 14 Lima
Tipo de actividad
Research Organisations
Contacto administrativo
Sergio Chavez (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Francia
Aportación de la UE
€ 759 760
Dirección
Rue Michel Ange 3
75794 Paris
Tipo de actividad
Other
Contacto administrativo
Sandrine Magnetto (Dr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
Aportación de la UE
€ 108 095,64
Dirección
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Tipo de actividad
Research Organisations
Contacto administrativo
Richard Frost (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Francia
Aportación de la UE
€ 96 811,04
Dirección
Rue De Tolbiac 101
75654 Paris
Tipo de actividad
Research Organisations
Contacto administrativo
Mihaja Auguste (Ms.)
Instituto Nacional de Saúde
Mozambique
Aportación de la UE
€ 241 334
Dirección
Avenida Eduardo Mondlane 1008
Maputo
Tipo de actividad
Research Organisations
Contacto administrativo
Maria Helena Abdul (Ms.)
ACIES Consulting Group SAS
Francia
Dirección
Rue De La République 69
69002 Lyon
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Vincent Grosbois (Mr.)
GENEART AG
Alemania
Aportación de la UE
€ 109 599
Dirección
Josef-engert-strasse 9
93053 Regensburg
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Melanie Meyer (Ms.)
ASOCIACION CIVIL IMPACTA SALUD Y EDUCACION
Perú
Aportación de la UE
€ 282 338
Dirección
Avenida Almirante Miguel Grau 1010
L04 Lima
Tipo de actividad
Research Organisations
Contacto administrativo
Jose Joaquin Ojeda Celi (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Aportación de la UE
€ 2 963 186,32
Dirección
South Kensington Campus Exhibition Road
SW7 2AZ London
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Tatjana Palalic (Ms.)
OBJECTIF RECHERCHE VACCIN SIDA
Francia
Aportación de la UE
€ 30 966,60
Dirección
Boulevard De L Hopital 47-83
75013 Paris
Tipo de actividad
Research Organisations
Contacto administrativo
François Lecardonnel (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Aportación de la UE
€ 239 822,86
Dirección
Gower Street
WC1E 6BT London
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Malgorzata Kielbasa (Ms.)