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Cutaneous and Mucosal HIV Vaccination

Obiettivo

Despite significant effort over the past decade to design and implement new vaccines strategies against HIV, no one has met its promise to prevent infection and/or to reduce viral load until reaching eradication of the HIV reservoir. To reach this goal, a translational research is critical to propose innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cellular immune responses specific to HIV antigens. Composed by 13 partners from 5 European countries and 2 International Cooperation countries, the CUT’HIVAC consortium gathers knowledge’s and cutting-edge technologies in vaccinology and HIV diseases to raise the challenge of developing a new HIV strategy. The CUT’HIVAC approach is based on innovative transcutaneous and/or mucosal needle-free vaccination methods in a perspective that new vaccine candidates will redirect immune response toward cytotoxic CD8 and mucosal humoral responses. The trust of the project derives from the proof-of-concept that combination of routes of immunization and delivery systems will shape the immune responses towards its protective arms against HIV. Clinical trials will be implemented with last cutting-edge generation of HIV DNA-GTU® candidate applied by transcutaneous, intradermal routes and/or mucosal administration of HIV-envelop protein-based vaccine. Large efforts will be positioned on the new genetic design of HIV antigens and delivery systems for developed and developing countries. These new vaccines will be tested in innovative preclinical approaches with a special highlight on routes of vaccination that will be translated into 2nd round of clinical trials in a perspective that could help to prevent and eradicate HIV. Through its integrative and multidisciplinary approach, CUT’HIVAC will therefore provide the basis for a novel approach in vaccination with a view to wide its application to other infectious diseases such as malaria and tuberculosis.

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Coordinatore

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
Indirizzo
Place Jussieu 4
75252 Paris
Francia

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Higher or Secondary Education Establishments
Contatto amministrativo
Lucie Salvaudon (Dr.)
Contributo UE
€ 1 963 463,30

Partecipanti (17)

UNIVERSITAET REGENSBURG
Germania
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€ 1 270 801
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Universitatsstrasse 31
93053 Regensburg

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Higher or Secondary Education Establishments
Contatto amministrativo
Christian Blomeyer (Dr.)
FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA
Spagna
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€ 974 680
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Carretera De Canyet
08916 Barcelona

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Research Organisations
Contatto amministrativo
Anna Tor (Ms.)
FIT BIOTECH OY
Finlandia
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€ 1 648 460
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Biokatu 8
33520 Tampere

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Liisa Irmeli Laitinen (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germania
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€ 621 400
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Chariteplatz 1
10117 Berlin

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Higher or Secondary Education Establishments
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Eveline Fräßdorf (Ms.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL

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United Kingdom
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€ 119 326,50
Indirizzo
Cranmer Terrace
SW17 0RE London

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Higher or Secondary Education Establishments
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Paul Craven (Dr.)
Investigaciones Medicas en Salud

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Perú
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€ 130 899,74
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Jose De La Torre Ugarte 166
L 14 Lima

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Sergio Chavez (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Francia
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€ 759 760
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Rue Michel Ange 3
75794 Paris

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Sandrine Magnetto (Dr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
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20 Park Crescent
W1B 1AL London

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Richard Frost (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Francia
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€ 96 811,04
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Rue De Tolbiac 101
75654 Paris

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Mihaja Auguste (Ms.)
Instituto Nacional de Saúde
Mozambico
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€ 241 334
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Avenida Eduardo Mondlane 1008
Maputo

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Maria Helena Abdul (Ms.)
NOVAMEN SAS

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Francia
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€ 368 306
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Rue De La République 69
69002 Lyon

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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Vincent Grosbois (Mr.)
ACIES Consulting Group SAS
Francia
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Rue De La République 69
69002 Lyon

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Vincent Grosbois (Mr.)
GENEART AG
Germania
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€ 109 599
Indirizzo
Josef-engert-strasse 11
93053 Regensburg

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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Melanie Meyer (Ms.)
ASOCIACION CIVIL IMPACTA SALUD Y EDUCACION
Perú
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€ 282 338
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Avenida Almirante Miguel Grau 1010
L04 Lima

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Jose Joaquin Ojeda Celi (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
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€ 2 963 186,32
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South Kensington Campus Exhibition Road
SW7 2AZ London

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Tatjana Palalic (Ms.)
OBJECTIF RECHERCHE VACCIN SIDA
Francia
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€ 30 966,60
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Boulevard De L Hopital 47-83
75013 Paris

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François Lecardonnel (Mr.)
UNIVERSITY COLLEGE LONDON
United Kingdom
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€ 239 822,86
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Gower Street
WC1E 6BT London

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Higher or Secondary Education Establishments
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Malgorzata Kielbasa (Ms.)