OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE)

Project Information

OPTIMISE

Grant agreement ID: 242114

Project closed

Start date 1 February 2010

End date 31 July 2016

Funded under

• Specific Programme "Cooperation": Health

Total cost € 14 900 190,31

EU contribution € 11 187 685,42

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

Objective

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project will lead to evidence that is directly applicable to treatment guidelines, will explore the development of novel treatments and will identify potential mechanisms for new drug development. To achieve these goals we have assembled a European team of experts that is second to none in the world. Together we will pursue the following objectives: -To use MRI to optimise treatment outcome and to facilitate prediction of response to treatment; - To provide a rational basis for antipsychotic choices in the treatment of first episode schizophrenia or schizophreniform disorder; - To improve functional outcome and reduce drug discontinuation by means of psychosocial interventions. - To explore the potential of cannabidiol CBD, a modulator of endocannabinoid functioning, as an alternative to D2 based antipsychotics - To validate a new approach to improve cognitive performance in patients with cognitive deficits on the basis of their genetic make up; - To use theoretically driven neurochemical imaging (MRS) and empirically driven genetic/genomic markers as predictors of response to treatment.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › clinical medicine › psychiatry › schizophrenia

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2009-2.2.1-3 - Optimising current therapeutic approaches to schizophrenia

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

• EU contribution: € 3 205 464,06
• Address: HEIDELBERGLAAN 100 ; 3584 CX Utrecht ; Netherlands
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

Participants (22)

KING'S COLLEGE LONDON

United Kingdom

• EU contribution: € 1 725 194,26
• Address: STRAND ; WC2R 2LS London
• Region: London › Inner London — West › Westminster
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: € 591 356,36
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Total cost: No data

THE UNIVERSITY OF MANCHESTER

United Kingdom

• EU contribution: € 408 047,00
• Address: OXFORD ROAD ; M13 9PL Manchester
• Region: North West (England) › Greater Manchester › Manchester
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Germany

• EU contribution: € 970 695,00
• Address: Square J 5 ; 68159 Mannheim
• Region: Baden-Württemberg › Karlsruhe › Mannheim, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

• EU contribution: € 450 136,00
• Address: ISMANINGER STRASSE 22 ; 81675 Muenchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

REGION HOVEDSTADEN

Denmark

• EU contribution: € 714 003,64
• Address: KONGENS VAENGE 2 ; 3400 Hillerod
• Region: Danmark › Hovedstaden › Nordsjælland
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Total cost: No data

SERVICIO MADRILENO DE SALUD

Spain

• EU contribution: € 742 961,28
• Address: Paseo De la Castellana, 280 ; 28046 MADRID
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Total cost: No data

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

• EU contribution: € 78 705,36
• Address: CHRISTOPH PROBST PLATZ 1 ; 6020 Innsbruck
• Region: Westösterreich › Tirol › Innsbruck
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

KATHOLIEKE UNIVERSITEIT LEUVEN

Participation ended

Belgium

• EU contribution: € 22 784,38
• Address: OUDE MARKT 13 ; 3000 Leuven
• Region: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER

Israel

• EU contribution: € 224 072,95
• Address: TEL HASHOMER SHEBA MEDICAL CENTER ; 52621 Ramat Gan
• Activity type: Research Organisations
• Total cost: No data

UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU

Poland

• EU contribution: € 175 846,80
• Address: UL. FREDRY 10 ; 61-701 Poznan
• Region: Makroregion północno-zachodni › Wielkopolskie › Miasto Poznań
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

Clienia Schloessli AG

Switzerland

• EU contribution: € 214 537,80
• Address: Schlösslistrasse 8 ; 8618 Oetwil am See
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

• EU contribution: € 200 319,90
• Address: GESCHWISTER SCHOLL PLATZ 1 ; 80539 MUNCHEN
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI

Italy

• EU contribution: € 234 899,76
• Address: VIALE ABRAMO LINCOLN 5 ; 81100 Caserta
• Region: Sud › Campania › Caserta
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

• EU contribution: € 213 204,00
• Address: INGOLSTADTER LANDSTRASSE 1 ; 85764 Neuherberg
• Region: Bayern › Oberbayern › München, Landkreis
• Activity type: Research Organisations
• Total cost: No data

TANGENT DATA SRL

Romania

• EU contribution: € 446 620,20
• Address: CALEA VICTORIEI 91-93 SC C ET P AP ; 10091 BUCURESTI
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

UNIVERZITA KARLOVA

Czechia

• EU contribution: € 103 949,44
• Address: OVOCNY TRH 560/5 ; 116 36 Praha 1
• Region: Česko › Praha › Hlavní město Praha
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

NARODNI USTAV DUSEVNIHO ZDRAVI

Participation ended

Czechia

• EU contribution: € 13 172,40
• Address: TOPOLOVA 748 ; 250 67 Klecany
• Region: Česko › Střední Čechy › Středočeský kraj
• Activity type: Research Organisations
• Total cost: No data

MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG

Germany

• EU contribution: € 71 900,40
• Address: UNIVERSITATSPLATZ 10 ; 6108 Halle
• Region: Baden-Württemberg › Stuttgart › Stuttgart, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

Fondation FondaMental

France

• EU contribution: € 215 537,23
• Address: Rue de Mesly, Hopital Chenevier, Pole de Psychiatrie 40 ; 94000 Creteil
• Region: Ile-de-France › Ile-de-France › Val-de-Marne
• Activity type: Research Organisations
• Total cost: No data

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

• EU contribution: € 71 900,40
• Address: IM NEUENHEIMER FELD 672 ; 69120 Heidelberg
• Region: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

MNOGOPROFILNA BOLNITSA ZA AKTIVNO LECHENIE PO NEVROLOGIA I PSIHIATRIA SV NAUM

Bulgaria

• EU contribution: € 92 376,80
• Address: TSARIGRADSKO SHOSSE BULEVARD IV KILOMETER 1, Louben Roussev str. ; 1113 Sofia
• Region: Югозападна и Южна централна България › Югозападен › София (столица)
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data