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OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE)

Objective

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project will lead to evidence that is directly applicable to treatment guidelines, will explore the development of novel treatments and will identify potential mechanisms for new drug development. To achieve these goals we have assembled a European team of experts that is second to none in the world. Together we will pursue the following objectives: -To use MRI to optimise treatment outcome and to facilitate prediction of response to treatment; - To provide a rational basis for antipsychotic choices in the treatment of first episode schizophrenia or schizophreniform disorder; - To improve functional outcome and reduce drug discontinuation by means of psychosocial interventions. - To explore the potential of cannabidiol CBD, a modulator of endocannabinoid functioning, as an alternative to D2 based antipsychotics - To validate a new approach to improve cognitive performance in patients with cognitive deficits on the basis of their genetic make up; - To use theoretically driven neurochemical imaging (MRS) and empirically driven genetic/genomic markers as predictors of response to treatment.

Field of science

  • /medical and health sciences/clinical medicine/psychiatry/schizophrenia

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 205 464,06
Administrative Contact
Mirjam Lormans (Ms.)

Participants (22)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 1 725 194,26
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silke Blohm (Mrs.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 591 356,36
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Didier Lemoine (Mr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 408 047
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms.)
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 970 695
Address
Square J 5
68159 Mannheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Simone Fuchs
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 450 136
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renate Rädlein
REGION HOVEDSTADEN
Denmark
EU contribution
€ 714 003,64
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Birte Glenthøj (Prof.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 742 961,28
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Albino Navarro (Dr.)
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 78 705,36
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Josten (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN

Participation ended

Belgium
EU contribution
€ 22 784,38
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Dr.)
MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
Israel
EU contribution
€ 224 072,95
Address
Tel Hashomer Sheba Medical Center
52621 Ramat Gan
Activity type
Research Organisations
Administrative Contact
Michael Davidson (Prof.)
UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU
Poland
EU contribution
€ 175 846,80
Address
Ul. Fredry 10
61-701 Poznan
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Janusz Rybakowski (Prof.)
Clienia Schloessli AG
Switzerland
EU contribution
€ 214 537,80
Address
Schlösslistrasse 8
8618 Oetwil Am See
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gregor Berger (Dr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 200 319,90
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexander Vogl (Mr.)
UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI
Italy
EU contribution
€ 234 899,76
Address
Viale Abramo Lincoln 5
81100 Caserta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luciana Taliento (Ms.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 213 204
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
TANGENT DATA SRL
Romania
EU contribution
€ 446 620,20
Address
Calea Victoriei 91-93 Sc C Et P Ap
10091 Bucuresti
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rodica Gonen (Mr.)
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 103 949,44
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Macourkova (Ms.)
NARODNI USTAV DUSEVNIHO ZDRAVI

Participation ended

Czechia
EU contribution
€ 13 172,40
Address
Topolova 748
250 67 Klecany
Activity type
Research Organisations
Administrative Contact
Alexandr Borovička (Mr.)
MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG
Germany
EU contribution
€ 71 900,40
Address
Universitaetsplatz 10
6108 Halle (Saale)
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dan Rujescu (Prof.)
Fondation FondaMental
France
EU contribution
€ 215 537,23
Address
Rue De Mesly, Hopital Chenevier, Pole De Psychiatrie 40
94000 Creteil
Activity type
Research Organisations
Administrative Contact
Maria Chovet
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 71 900,40
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz (Mr.)
SPETSIALIZIRANA BOLNITSA ZA AKTIVNO LECHENIE PO NEVROLOGIA I PSIHIATRIA SV NAUM AD
Bulgaria
EU contribution
€ 92 376,80
Address
Tsarigradsko Shosse Bulevard Iv Kilometer
1113 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Luchezar Hranov