Obiettivo
This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of resistance. The proposal includes development of both slow release and gel formulations, pharmacokinetic and challenge experiments in macaques as well as human studies including a collaborative study with an EDCTP-funded project to use multiplex and proteomic technologies as well as culture-independent DNA-based analysis of mucosal microbiota to investigate biomarkers and establish a baseline signature from which perturbations can be recognised. This is a large consortium comprising 30 partners from 8 EU countries and from Switzerland, Ukraine, South Africa and the United States.Partners include microbicide developers, IPM and Particle Sciences, and producers, Gilead, Tibotec and Virco. Two SMEs will also participate in RTD aspects. The consortium is multidisciplinary with scientists engaged in basic discovery working with new targets and developing novel chemistry to produce compounds with improved safety and efficacy profiles as well as altered patterns of resistance.
Argomento(i)
Invito a presentare proposte
FP7-HEALTH-2009-single-stage
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Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
WC2R 2LS London
Regno Unito
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Partecipanti (33)
SW17 0RE London
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75015 PARIS 15
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2000 ANTWERPEN
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2000 Antwerpen
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BT7 1NN Belfast
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4051 Basel
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53100 Siena
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3000 Leuven
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WC1E 6BT LONDON
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20132 MILANO
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YO10 5DD York North Yorkshire
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3584 CS Utrecht
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28029 Madrid
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20009 San Sebastian
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0001 Pretoria
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00185 Roma
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01042 Kiev
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1040 BRUSSELS
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Partecipazione conclusa
1105 BP Amsterdam
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3400 Klosterneuburg
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94404 Foster City Ca
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18017 Bethlehem
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1211 Geneve
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20910 Silver Spring
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17177 Stockholm
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40237 Dusseldorf
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1228 Plan-Les-Ouates
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2340 BEERSE
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53035 Monteriggioni
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NW4 4BT London
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SW7 2AZ LONDON
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L69 7ZX Liverpool
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20132 Milano
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