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Vitamin D And LIfestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention

Objective

Europe is facing a rapidly growing threat from Type 2 diabetes mellitus (T2D), which is undoubtedly associated with an unhealthy diet and a more sedentary lifestyle. Evidence is accumulating that gestational diabetes mellitus (GDM) may be playing a role in this process. Thus it provides a significant opportunity for preventing future T2D. Not only is GDM prevalence on the rise, but intrauterine exposure to hyperglycaemia predisposes the offspring to diabetes and obesity. Another putative contributing factor is a low vitamin D status, which is also increasing in prevalence and may have causal links with both obesity and decreased glucose tolerance. The main aims of this project are: 1) to establish the current status of the prevalence of GDM in Europe and facilitate the adoption of a single diagnostic approach and 2) to deliver the best strategy that prevents GDM. The latter was deemed as not fully feasible within the scope of this call and our decision was to test the most relevant approaches (diet, exercise, vitamin D, alone or in combination) against surrogate variables of GDM (fasting blood glucose, insulin sensitivity, pregnancy weight gain) to come up with the best intervention for entry into a definitive GDM prevention trial. Deliverables include the sample size and modus operandi for such a trial. Value will be added to the project by 1) Assessing variables modifying the uptake of preventive interventions, 2) Exploring health costs of GDM and potential savings of preventive approaches, 3) Improving pathophysiological understanding by assessing intervention effect on several parameters in mother and foetus and 4) Facilitating future research through a well defined cohort of mother-offspring pairs and comprehensive biobanking.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MEDIZINISCHE UNIVERSITAT GRAZ
Address
Auenbruggerplatz 2
8036 Graz
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 746 663,44
Administrative Contact
Gernot Desoye (Prof.)

Participants (15)

FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU
Spain
EU contribution
€ 171 919
Address
Calle Sant Antoni M Claret 167
08025 Barcelona
Activity type
Research Organisations
Administrative Contact
Hilda Herrero (Ms.)
MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Stefanie Odermatt (Ms.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 162 000
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Josef Smolen (Prof.)
HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ

Participation ended

Finland
EU contribution
€ 2 192
Address
Stenbackinkatu 9
00029 Helsinki
Activity type
Research Organisations
Administrative Contact
Merja Takala (Ms.)
Recherche en Santé Lawson SA
Switzerland
EU contribution
€ 83 100
Address
Industriestrasse 6 B
9552 Bronschhofen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christian Spenger (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 259 728
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Dr.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 202 320
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Peter Damm (Prof.)
UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU
Poland
EU contribution
€ 129 555
Address
Ul. Fredry 10
61-701 Poznan
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ewa Wender - Ozegowska (Prof.)
BAP HEALTH OUTCOMES RESEARCH SL

Participation ended

Spain
EU contribution
€ 17 377,16
Address
Calle Azcarraga 12
33600 Oviedo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pablo Rebollo (Dr.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 125 474
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giuseppe Realdi (Prof.)
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 152 556
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roger Sweetman (Mr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Snoek (Prof.)
Cambridge University Hospitals NHS Foundation Trust
United Kingdom
EU contribution
€ 492 845
Address
Hills Road Addenbrookes Hospital
CB2 0QQ Cambridge
Activity type
Other
Administrative Contact
Stephen Kelleher (Mr.)
REGION SYDDANMARK
Denmark
EU contribution
€ 100 797
Address
Damhaven 12
7100 Vejle
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Dorte Møller Jensen (Prof.)
STICHTING VU
Netherlands
EU contribution
€ 352 902,40
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michel Telkamp