Objetivo We propose a systems biology study of the specificity of response of the cell-mediated immune system to fungal microorganisms in order to investigate the genetic basis of susceptibility to fungal disease and elucidate molecular mechanisms of drug resistance in fungal pathogens. An integrative approach, combining high-throughput and traditional wet-lab work with computational and bioinformatics methods, will be applied to identify biomarkers of resistance to currently available treatments and to develop novel putative drug target genes and pathways in different fungi. We will use Saccharomyces cerevisiae, a normally non-pathogenic yeast model organism, Candida albicans and Aspergillus fumigatus, two major recognized fungal pathogens as well as other Aspergillus spp. known to be multi-drug resistant and difficult to treat. This project meets the criteria of the call, the strategic objective of which is “to confront the increasing emergence and spread of antimicrobial drug resistant pathogens in Europe” by addressing a well-defined class of infectious disease caused by fungal pathogens, with significant morbidity and mortality in a large segment of the population, and a high economic cost due to resistance. The anticipated results are highly relevant to society in terms of reducing the burden of mortality and suffering in immunosuppressed patients and in terms of reducing medical costs associated with treating opportunistic fungal infections. The potential economic upside for novel broad-spectrum anti-infectives is very large. The worldwide market for antifungals is currently estimated at $4 billion US annually. We tackle the issues of anti-microbial drug resistance head on via a multidisciplinary systems biology study combining bacterial genetics, clinical and pharmacological research in a systems biology approach, integrating traditional wet-lab methods with those of functional genomics, proteomics, metabolomics and bioinformatics. Ámbito científico social sciencessociologydemographymortalitymedical and health scienceshealth sciencesinfectious diseasesnatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance Palabras clave GWAS antifungal resistance functional genomics immunopharmacology pathway analysis systems biology Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH-2009-2.3.1-2 - Impact of specific antibiotic therapies on the prevalence of resistant bacteria in the human host Convocatoria de propuestas FP7-HEALTH-2009-single-stage Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador EUROPEAN MOLECULAR BIOLOGY LABORATORY Aportación de la UE € 867 883,00 Dirección Meyerhofstrasse 1 69117 Heidelberg Alemania Ver en el mapa Región Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Tipo de actividad Research Organisations Contacto administrativo Tom Ratcliffe (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITA DEGLI STUDI DI FIRENZE Italia Aportación de la UE € 336 800,00 Dirección Piazza San Marco 4 50121 Florence Ver en el mapa Región Centro (IT) Toscana Firenze Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Alessandro Mugelli (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos THE UNIVERSITY OF MANCHESTER Reino Unido Aportación de la UE € 591 716,40 Dirección OXFORD ROAD M13 9PL Manchester Ver en el mapa Región North West (England) Greater Manchester Manchester Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Liz Fay (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSIDADE DE AVEIRO Portugal Aportación de la UE € 291 457,00 Dirección CAMPUS UNIVERSITÁRIO DE SANTIAGO 3810-193 Aveiro Ver en el mapa Región Continente Centro (PT) Região de Aveiro Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Manuel António Da Silva Santos (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Francia Aportación de la UE € 299 842,00 Dirección RUE MICHEL ANGE 3 75794 Paris Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Contacto administrativo Béatrice Saint-Cricq (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ALERGENETICA SL España Aportación de la UE € 486 000,00 Dirección "CALDERON DE LA BARCA 5, 5, #27" 38005 SANTA CRUZ DE TENERIFE Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Brian Miller (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos UNIVERSITA DEGLI STUDI DI PERUGIA Italia Aportación de la UE € 200 000,00 Dirección PIAZZA DELL UNIVERSITA 1 06123 Perugia Ver en el mapa Región Centro (IT) Umbria Perugia Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Rosario Francesco Donato (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES La participación finalizó Francia Aportación de la UE Sin datos Dirección RUE LEBLANC 25 75015 PARIS 15 Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Contacto administrativo Elizabeth May (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos FUNDACIO PARC CIENTIFIC DE BARCELONA España Aportación de la UE € 1 217 463,00 Dirección BALDIRI I REIXAC 4 08028 Barcelona Ver en el mapa Región Este Cataluña Barcelona Contacto administrativo Moises Tarte (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos