Obiettivo We propose a systems biology study of the specificity of response of the cell-mediated immune system to fungal microorganisms in order to investigate the genetic basis of susceptibility to fungal disease and elucidate molecular mechanisms of drug resistance in fungal pathogens. An integrative approach, combining high-throughput and traditional wet-lab work with computational and bioinformatics methods, will be applied to identify biomarkers of resistance to currently available treatments and to develop novel putative drug target genes and pathways in different fungi. We will use Saccharomyces cerevisiae, a normally non-pathogenic yeast model organism, Candida albicans and Aspergillus fumigatus, two major recognized fungal pathogens as well as other Aspergillus spp. known to be multi-drug resistant and difficult to treat. This project meets the criteria of the call, the strategic objective of which is “to confront the increasing emergence and spread of antimicrobial drug resistant pathogens in Europe” by addressing a well-defined class of infectious disease caused by fungal pathogens, with significant morbidity and mortality in a large segment of the population, and a high economic cost due to resistance. The anticipated results are highly relevant to society in terms of reducing the burden of mortality and suffering in immunosuppressed patients and in terms of reducing medical costs associated with treating opportunistic fungal infections. The potential economic upside for novel broad-spectrum anti-infectives is very large. The worldwide market for antifungals is currently estimated at $4 billion US annually. We tackle the issues of anti-microbial drug resistance head on via a multidisciplinary systems biology study combining bacterial genetics, clinical and pharmacological research in a systems biology approach, integrating traditional wet-lab methods with those of functional genomics, proteomics, metabolomics and bioinformatics. Campo scientifico social sciencessociologydemographymortalitymedical and health scienceshealth sciencesinfectious diseasesnatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance Parole chiave GWAS antifungal resistance functional genomics immunopharmacology pathway analysis systems biology Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2009-2.3.1-2 - Impact of specific antibiotic therapies on the prevalence of resistant bacteria in the human host Invito a presentare proposte FP7-HEALTH-2009-single-stage Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore EUROPEAN MOLECULAR BIOLOGY LABORATORY Contributo UE € 867 883,00 Indirizzo Meyerhofstrasse 1 69117 Heidelberg Germania Mostra sulla mappa Regione Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Tipo di attività Research Organisations Contatto amministrativo Tom Ratcliffe (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITA DEGLI STUDI DI FIRENZE Italia Contributo UE € 336 800,00 Indirizzo Piazza San Marco 4 50121 Florence Mostra sulla mappa Regione Centro (IT) Toscana Firenze Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Alessandro Mugelli (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF MANCHESTER Regno Unito Contributo UE € 591 716,40 Indirizzo OXFORD ROAD M13 9PL Manchester Mostra sulla mappa Regione North West (England) Greater Manchester Manchester Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Liz Fay (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSIDADE DE AVEIRO Portogallo Contributo UE € 291 457,00 Indirizzo CAMPUS UNIVERSITÁRIO DE SANTIAGO 3810-193 Aveiro Mostra sulla mappa Regione Continente Centro (PT) Região de Aveiro Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Manuel António Da Silva Santos (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Francia Contributo UE € 299 842,00 Indirizzo RUE MICHEL ANGE 3 75794 Paris Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Contatto amministrativo Béatrice Saint-Cricq (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ALERGENETICA SL Spagna Contributo UE € 486 000,00 Indirizzo "CALDERON DE LA BARCA 5, 5, #27" 38005 SANTA CRUZ DE TENERIFE Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Brian Miller (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI PERUGIA Italia Contributo UE € 200 000,00 Indirizzo PIAZZA DELL UNIVERSITA 1 06123 Perugia Mostra sulla mappa Regione Centro (IT) Umbria Perugia Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Rosario Francesco Donato (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Partecipazione conclusa Francia Contributo UE Nessun dato Indirizzo RUE LEBLANC 25 75015 PARIS 15 Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Contatto amministrativo Elizabeth May (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FUNDACIO PARC CIENTIFIC DE BARCELONA Spagna Contributo UE € 1 217 463,00 Indirizzo BALDIRI I REIXAC 4 08028 Barcelona Mostra sulla mappa Regione Este Cataluña Barcelona Contatto amministrativo Moises Tarte (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato