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Chromatin Mediators of Estrogen Receptor Biology

Ziel

Estrogen Receptor (ER) drives proliferation in breast cancers and drugs such as tamoxifen and Aromatase Inhibitors, that target ER activity, are first line treatments in clinical practice. However drug resistance is a significant clinical problem. My laboratory has reported that chromatin-modifying pioneer factors are required for ER to bind the genome, and may constitute a unique opportunity for treating drug resistant cancer. My proposal consists of two complementary approaches to comprehensively explore how Estrogen Receptor interacts with these factors to direct transcription. (1) We will demonstrate that FoxA1 and the Groucho protein TLE1 are critical mediators of ER-chromatin interactions by mapping TLE1 binding sites on a genome-wide basis, and functionally testing the roles these factors play with ER in genomic remodeling, gene transcription, cell proliferation, and endocrine resistance. (2) More globally, to characterise ER transcriptional partners on a molecular basis, we will identify the complete complement of ER-associated proteins using novel proteomic approaches. Taken together, these approaches will explore how ER employs pioneer factors mechanistically, and will identify other potential players.

Schlüsselbegriffe

Aufforderung zur Vorschlagseinreichung

ERC-2009-StG
Andere Projekte für diesen Aufruf anzeigen

Gastgebende Einrichtung

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
EU-Beitrag
€ 731 548,47
Adresse
TRINITY LANE THE OLD SCHOOLS
CB2 1TN Cambridge
Vereinigtes Königreich

Auf der Karte ansehen

Region
East of England East Anglia Cambridgeshire CC
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Renata Schaeffer (Ms.)
Hauptforscher
Jason Scott Carroll (Dr.)
Links
Gesamtkosten
Keine Daten

Begünstigte (2)