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IMPACT OF AGENTS WITH POTENTIAL USE IN FUNCTIONAL FOODS ON BIOMARKERS FOR INDUCTION OF AGE RELATED DISEASES

Objetivo

A number of epidemiological studies have consistently demonstrated the protective effects of fruits and vegetables with respect to several age related diseases. The aim of this project is to investigate the protective action of agents with potential use as functional food constituents with respect to cancer, diabetes and cardiovascular disease. In collaboration between EU and Indian research centers the proposal features a multipronged approach, where the protective action of various non-toxic agents are studied in vitro as well as in rodent models with respect to induction of DNA lesions, tumours and biomarkers for the development of diabetes, diabetic retinopathy and atherosclerosis. In addition, reduced availability of carcinogens and inhibition of their metabolic activation are investigated. Testing of the protective efficacy of functional food components in intervention cross-over studies in humans exposed to carcinogens, that are normally present at significant levels in the environment, represents an approach that has rarely been resorted to, and will be implemented under this project in Europe as well as in India using sophisticated molecular, cytogenetic and other analytical methods. Although there has been remarkable progress in our understanding of the processes that lead to neoplasia and diabetes, the mechanisms underlying chemoprevention are, in general, little understood. The results from this project are expected to provide an improved insight with respect to this topic.

Convocatoria de propuestas

FP7-KBBE-2009-3
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Coordinador

STOCKHOLMS UNIVERSITET
Dirección
Universitetsvagen 10
10691 Stockholm
Suecia

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Dag Jenssen (Prof.)
Aportación de la UE
€ 599 400

Participantes (4)

UNIVERSITA DEGLI STUDI DELLA TUSCIA
Italia
Aportación de la UE
€ 229 692
Dirección
Via S Maria In Gradi 4
01100 Viterbo

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Daniela Cicalini (Dr.)
BIOCHEMICHES INSTITUT FUR UMWELTCARCINOGENE PROF. DR. GERNOT GRIMMER STIFTUNG
Alemania
Aportación de la UE
€ 230 016
Dirección
Lurup 4
22927 Grosshansdorf

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Tipo de actividad
Research Organisations
Contacto administrativo
Albrecht Seidel (Dr.)
INSTITUT ZA NUKLEARNE NAUKE VINCA
Serbia
Aportación de la UE
€ 183 600
Dirección
Mihajla Petrovica Alasa 12-14
11001 Belgrade

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Tipo de actividad
Research Organisations
Contacto administrativo
Gordana Joksic (Dr.)
KAROLINSKA INSTITUTET
Suecia
Aportación de la UE
€ 255 000
Dirección
Nobels Vag 5
17177 Stockholm

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Kerstin Brismar (Prof.)