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AMINE SYNTHESIS THROUGH BIOCATALYTIC CASCADES

Objectif

This project intends to engineer transaminase libraries that will be applied as the main enzymatic technology to deliver the amine functionality in the commercially valuable products of both chiral and bulk amine targets. These enzymes will be used in enzymatic cascades where simple starting materials are converted into the required intermediates for transamination or further enzymatic steps will be used to remove products from the transaminase reaction which will add value by extra functionality. This will also be supported by the development of enzymatic cascades to deliver efficient co-factor recycling and achieve the high conversions required for industrial use. A high throughput screening method based on a further enzymatic cascade will be developed. Engineering solutions will be used to overcome obstacles associated with the implementation of this core technology on a larger scale and integrate the use of other enzymes into the synthetic pathway to allow multi-step, multi-enzyme cascades to be used to deliver complex multi-functional amine products and processes. The industrial partner will target the development of enzymes from the project for specific application into their new products range. Life cycle analysis and environmental impact analysis will compare the final methods with conventional chemical synthesis and allow advantages to be objectively defined.

Appel à propositions

FP7-KBBE-2009-3
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Coordinateur

THE UNIVERSITY OF MANCHESTER
Adresse
Oxford Road
M13 9PL Manchester
United Kingdom

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Liz Fay (Ms.)
Contribution de l’UE
€ 589 350

Participants (7)

UNIVERSITAET GRAZ
Autriche
Contribution de l’UE
€ 528 240
Adresse
Universitatsplatz 3
8010 Graz

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Wolfgang Kroutil (Prof.)
DANMARKS TEKNISKE UNIVERSITET
Danemark
Contribution de l’UE
€ 697 500
Adresse
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
John Woodley (Prof.)
EVONIK OPERATIONS GMBH
Allemagne
Adresse
Rellinghauser Strasse 1-11
45128 Essen

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Jan Pfeffer (Dr.)
RIJKSUNIVERSITEIT GRONINGEN
Pays-Bas
Contribution de l’UE
€ 328 192
Adresse
Broerstraat 5
9712CP Groningen

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jan Poutsma (Dr.)
CLEA TECHNOLOGIES BV
Pays-Bas
Contribution de l’UE
€ 256 604
Adresse
Delftechpark 34
2628 XH Delft

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Ivo Van Der Laan (Mr.)
CHIROTECH TECHNOLOGY LIMITED
United Kingdom
Contribution de l’UE
€ 60 656
Adresse
Milton Road 410 Cambridge Science Park -
CB4 0PE Cambridge

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Srinivas Dronamraju (Mr.)
EVONIK INDUSTRIES AG
Allemagne
Contribution de l’UE
€ 64 250
Adresse
Rellinghauser Strasse 1-11
45128 Essen

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Patrick Sittig