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Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites

Objectif

MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability will be assessed as to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of PAH pollution. We will generate a knowledge base not only on the microbial catabolome for biodegradation of PAHs in various impacted environmental settings based on genome gazing, retrieval and characterization of specific enzymes but also on systems related bioavailability of contaminant mixtures. MAGICPAH takes into account the tremendous undiscovered metagenomic resources by the direct retrieval from genome/metagenome libraries and consequent characterization of enzymes through activity screens. These screens will include a high-end functional small-molecule fluorescence screening platform and will allow us to directly access novel metabolic reactions followed by their rational exploitation for biocatalysis and the re-construction of biodegradation networks. Results from (meta-) genomic approaches will be correlated with microbial in situ activity assessments, specifically dedicated to identifying key players and key reactions involved in anaerobic PAH metabolism. Key processes for PAH metabolism particularly in marine and composting environments and the kinetics of aerobic degradation of PAH under different conditions of bioavailability will be assessed in model systems, the rational manipulation of which will allow us to deduce correlations between system performance and genomic blueprint. The results will be used to improve treatments of PAH-contaminated sites.

Appel à propositions

FP7-KBBE-2009-3
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Régime de financement

CP-FP - Small or medium-scale focused research project

Coordinateur

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Adresse
Inhoffenstrasse 7
38124 Braunschweig
Allemagne
Type d’activité
Research Organisations
Contribution de l’UE
€ 435 890
Contact administratif
Michael Strätz (Dr.)

Participants (13)

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Espagne
Contribution de l’UE
€ 296 745
Adresse
Calle Serrano 117
28006 Madrid
Type d’activité
Research Organisations
Contact administratif
Carlos Manuel Abad Ruiz (Mr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italie
Contribution de l’UE
€ 303 534
Adresse
Piazzale Aldo Moro 7
00185 Roma
Type d’activité
Research Organisations
Contact administratif
Gaetana Irrera (Ms.)
BANGOR UNIVERSITY
United Kingdom
Contribution de l’UE
€ 301 296
Adresse
College Road
LL57 2DG Bangor
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Christine Davey (Ms.)
DANMARKS TEKNISKE UNIVERSITET
Danemark
Contribution de l’UE
€ 274 524
Adresse
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Birte Kastrup Rasmussen (Ms.)
AECOM CZ SRO
Tchéquie
Contribution de l’UE
€ 171 155
Adresse
Trojska 92
171 00 Prague 7
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Vendulka Spiskova (Dr.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Contribution de l’UE
€ 284 505
Adresse
Rue Leblanc 25
75015 Paris 15
Type d’activité
Research Organisations
Contact administratif
Regis Copin (Mr.)
HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ
Allemagne
Contribution de l’UE
€ 305 475
Adresse
Permoserstrasse 15
04318 Leipzig
Type d’activité
Other
Contact administratif
Annette Schmidt (Ms.)
AARHUS UNIVERSITET
Danemark
Contribution de l’UE
€ 320 160
Adresse
Nordre Ringgade 1
8000 Aarhus C
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Britt Sønberg Vilstrup (Ms.)
SYNDIAL SPA - ATTIVITA DIVERSIFICATE
Italie
Contribution de l’UE
€ 50 005
Adresse
Piazza Boldrini 1
20097 San Donato Milanese
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Giovanni Trovato (Dr.)
CORPORACION CORPOGEN
Colombie
Contribution de l’UE
€ 139 086
Adresse
Carrera 5 N° 66A-34
N/A Bogota
Type d’activité
Research Organisations
Contact administratif
Luis Fernando Diaz (Mr.)
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Canada
Adresse
Kings College Circle 27
M5S 1A1 Toronto
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Alexei Savchenko (Dr.)
UNIVERSITAET LEIPZIG

Participation terminée

Allemagne
Contribution de l’UE
€ 89 871,04
Adresse
Ritterstrasse 26
04109 Leipzig
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Gerhard Fuchs (Mr.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Allemagne
Contribution de l’UE
€ 24 890,96
Adresse
Fahnenbergplatz
79098 Freiburg
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Gabriela Hafke-Wessel (Mrs.)