Imaging liver immunopathology by intravital microscopy (IVM): a new approach to study the pathogenesis of hepatitis B virus (HBV) infection

Informazioni relative al progetto

LIVER IVM AND HBV

ID dell’accordo di sovvenzione: 250219

Progetto chiuso

Data di avvio 1 Settembre 2010

Data di completamento 31 Marzo 2016

Finanziato da

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Costo totale € 2 046 200,00

Contributo UE € 2 046 200,00

Coordinato da

OSPEDALE SAN RAFFAELE SRL
Italy

Obiettivo

Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis of
HBV infection with the ultimate hope that this knowledge will lead to the development of new therapeutic
strategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissect
poorly understood cellular and molecular pathways responsible for both liver disease and viral clearance taking
advantage of technological advances in the field of live imaging and unique mouse models of HBV infection.
Three specific aims will be pursued:
1. Visualize and characterize where and how naïve and effector CTL of different specificities adhere to
vessels and recognize/kill HBV-expressing hepatocytes within the “normal”, fibrotic/cirrhotic or
cancerous liver.
2. Characterize the role of platelets in HBV pathogenesis.
3. Characterize the role of Kupffer cells in HBV pathogenesis.

Campo scientifico

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › health sciences › infectious diseases › DNA viruses › hepatitis B
• natural sciences › physical sciences › optics › microscopy
• medical and health sciences › clinical medicine › hepatology

Programma(i)

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Argomento(i)

• ERC-AG-LS6 - ERC Advanced Grant - Immunity and infection

Invito a presentare proposte

ERC-2009-AdG
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Meccanismo di finanziamento

ERC-AG - ERC Advanced Grant

Istituzione ospitante

OSPEDALE SAN RAFFAELE SRL

• Contributo UE: € 1 298 620,83
• Indirizzo: VIA OLGETTINA 60 ; 20132 Milano ; Italia
• Regione: Nord-Ovest › Lombardia › Milano
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Ricercatore principale: Luca Guidotti (Prof.)
• Contatto amministrativo: Maria Rosa Pedrazzi (Ms.)
• Costo totale: Nessun dato

Beneficiari (2)

OSPEDALE SAN RAFFAELE SRL

Italia

• Contributo UE: € 1 298 620,83
• Indirizzo: VIA OLGETTINA 60 ; 20132 Milano
• Regione: Nord-Ovest › Lombardia › Milano
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Ricercatore principale: Luca Guidotti (Prof.)
• Contatto amministrativo: Maria Rosa Pedrazzi (Ms.)
• Costo totale: Nessun dato

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

Italia

• Contributo UE: € 747 579,17
• Indirizzo: Via Olgettina 60 ; 20132 MILANO
• Regione: Nord-Ovest › Lombardia › Milano
• Tipo di attività: Research Organisations
• Contatto amministrativo: Mario Valsecchi (Mr.)
• Costo totale: Nessun dato