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Drug Discovery in Interacting Proteins

Ziel

The Pharmaceutical sector is a mainstay of the European economy. However, changing patterns of drug discovery and competition has greatly enhanced the need for a SME sector to produce new drug leads and targets to feed big Pharma pipelines. This application addresses the need by coalescing partners involved in the identification/validation of new targets and in drug design, synthesis and discovery. The focus is on type 2 diabetes, obesity and immune diseases which cause serious disability and reduced life expectancy globally. Dualsystems and NUIM will be involved in the identification/validation of protein interactions involved in the pathway linking retinol binding protein and insulin, through which the former, when elevated in obesity, inhibits responses to the latter thereby contributing to type 2 diabetes. A second project will identify the protein machinery involved in the failure of otherwise active natural mutants of the MC4 receptor to traffic to the cell surface. This failure produces 6-7% of cases of gross genetic obesity. The third project will identify native protein ligands for a new family of G-protein coupled receptors (LNB-GPCRs), deeply implicated in immune-related diseases and cancer. The transfer of knowledge (TOK) involve development and use of yeast 2-hybrid systems to identify putative interactors and of rapid in vitro systems for interacting protein validation. A new yeast-based biosensor system will be advanced from “proof of concept” to the development stage. AFChemPharm focuses on new systems of chemical synthesis. They will work with NUIM on protein modelling, drug design, in silico screening and chemical synthesis to produce selected panels of compounds to screen for “hits” and to optimise into “leads. The TOK and skills acquisition will involve state of the art computational approaches in modelling, drug design and screening, together with their amalgamation with new synthetic processes to tailor/refine design and synthesis.

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-IAPP
Andere Projekte für diesen Aufruf anzeigen

Koordinator

NATIONAL UNIVERSITY OF IRELAND MAYNOOTH
Adresse
Co Kildare
W23 Maynooth
Irland

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
John Findlay (Prof.)
EU-Beitrag
€ 159 569

Beteiligte (2)

Dualsystems Biotech AG
Schweiz
EU-Beitrag
€ 171 580
Adresse
Grabenstrasse 11a
8952 Zurich-schlieren

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Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Daniel Auerbach (Dr.)
AF ChemPharm Ltd
United Kingdom
EU-Beitrag
€ 312 338
Adresse
Bailey Street - Bailey House 5-11
S14EH Sheffield

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Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Asad Fallah (Dr.)