Objective
ATP fuels all cellular processes and is fundamental for life and well-being. Mitochondria, which play a central role in cell regulation, are the principal source of cellular ATP. It is increasingly clear that defects in mitochondrial function underlie many major diseases (e.g. of the heart and central nervous system).
The ATP produced by mitochondria is synthesised by the F1-F0 ATP synthase. The enzyme is a proton motive ATPase, which is driven as an ATP synthase by the proton motive force, expressed primarily as a potential. If the potential collapses, e.g. under pathological conditions such as anoxia, the enzyme reverts from ATP synthesis to ATP hydrolysis, glycolysis becomes the only source of cellular ATP and mitochondria act as ATP consumers.
IF-1 is a protein, which inhibits ATPase activity. It binds the F1 sector of the ATPase, limits its hydrolytic activity and so protects the cell from ATP depletion. IF-1 is therefore a key determinant of cell survival during potentially lethal events such as ischemia, a major cause of death in industrialized countries. Furthermore, as the pathway of cell death to apoptosis or to necrotic cell death depends on ATP availability, IF-1 may play an important role in defining the pathway to cell death.
Remarkably, despite extensive and detailed knowledge IF-1 at a molecular level little is known about its comparative cell physiology between cell types and between species. The aim of my research training at the Physiology Department of the University College London is to characterize the functional contribution of IF-1 in physiological and pathological conditions.
Specifically, we plan
- to examine IF-1 expression and localization in different tissues and different species
- to use molecular biological techniques to generate recombinant probes of IF-1
- to examine the physiological and pathological consequences of alterations of IF-1 gene expression.
- Finally, to asses the role of IF-1 in cell death and tumourigenesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine neurology stroke
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.