An Integrated Computational and Spectroscopic Investigation of the Enzyme Mechanism of Tryptophan Hydroxylase

Projektinformationen

ICSTH

ID Finanzhilfevereinbarung: 255459

Abgeschlossenes Projekt

Startdatum 16 Mai 2011

Enddatum 31 Juli 2014

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 334 689,80

EU-Beitrag € 334 689,80

Koordiniert durch

UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE
United Kingdom

Ziel

Metalloenzymes play crucial role in neurobiology and therefore they are very important target for drug design for treatment neuropathological processes. In order to make new specific and effective drugs it is crucially important to understand the structure and functions of their drug targets. In this Outgoing Marie Curie Fellowship application we propose combined computational/spectroscopic investigation of the enzyme mechanism of tryptophan hydroxylase – a pterin-dependent non-heme containing iron enzyme in crucial importance for the nervous system. Accurate insight in the mechanism of such a complicated enzyme can not be received using solely computational or experimental methods therefore we will apply integrated combination of state-of-the-art computational methods with most modern spectroscopy methods (e.g. K edge X-ray Absorption Spectroscopy, Magnetic Circular Dichroism and variable-temperature variable-field MCD, and EPR). The results will provide understanding of the structure-functions relationships of this enzyme and will be used in drug design.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › neurobiology
• medical and health sciences › basic medicine › medicinal chemistry
• natural sciences › computer and information sciences › computational science
• natural sciences › physical sciences › optics › spectroscopy › absorption spectroscopy
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2009-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-IOF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IOF - International Outgoing Fellowships (IOF)

Koordinator

UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE

Kontakt Verwaltung

Gary Black (Prof.)

• EU-Beitrag: € 334 689,80
• Adresse: SUTHERLAND BUILDING COLLEGE STREET ; NE1 8ST Newcastle Upon Tyne ; Vereinigtes Königreich
• Region: North East (England) › Northumberland and Tyne and Wear › Tyneside
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten