Mapping of Hepatitis C virus NS4B protein interactions with its host network

Informations projet

HCV PATHOLOGY

N° de convention de subvention: 256449

Projet clôturé

Date de début 1 Avril 2010

Date de fin 31 Mars 2014

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total € 100 000,00

Contribution de l’UE € 100 000,00

Coordonné par

BAR ILAN UNIVERSITY
Israël

Objectif

Over 150 million individuals are infected with hepatitis C virus (HCV) worldwide. HCV is involved in chronic liver inflammation, fibrosis and formation of liver tumors. Similarly to other positive strand RNA viruses, HCV is believed to replicate its genome in association with cytoplasmic membranes. Nevertheless, the mechanisms of assembly and maintenance of the RNA replication complex as well as the mechanisms of cell transformation remain largely unknown. While previously characterized by a complete lack of known function, the HCV non-structural (NS) protein NS4B has emerged as the key player in the initiation of this critical process of membrane-associated complex assembly. We would like to map NS4B interaction with the human proteome. We hypothesize that some of the interactions discovered in this high-throughput screen will lead us to better understand the mechanism behind NS4B's role in HCV replication and cell transformation.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• sciences naturelles › sciences biologiques › microbiologie › virologie
• sciences médicales et de la santé › sciences de la santé › maladie infectieuse
• sciences naturelles › sciences biologiques › biochimie › biomolécule › protéines
• sciences naturelles › sciences biologiques › génétique › ARN

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants"

Appel à propositions

FP7-PEOPLE-2009-RG
Voir d’autres projets de cet appel

Régime de financement

MC-IRG -

Coordinateur

BAR ILAN UNIVERSITY

• Contribution de l’UE: € 100 000,00
• Adresse: BAR ILAN UNIVERSITY CAMPUS ; 52900 Ramat Gan ; Israël
• Type d’activité: Établissements d’enseignement supérieur ou secondaire
• Coût total: Aucune donnée