Objectif
Over 150 million individuals are infected with hepatitis C virus (HCV) worldwide. HCV is involved in chronic liver inflammation, fibrosis and formation of liver tumors. Similarly to other positive strand RNA viruses, HCV is believed to replicate its genome in association with cytoplasmic membranes. Nevertheless, the mechanisms of assembly and maintenance of the RNA replication complex as well as the mechanisms of cell transformation remain largely unknown. While previously characterized by a complete lack of known function, the HCV non-structural (NS) protein NS4B has emerged as the key player in the initiation of this critical process of membrane-associated complex assembly. We would like to map NS4B interaction with the human proteome. We hypothesize that some of the interactions discovered in this high-throughput screen will lead us to better understand the mechanism behind NS4B's role in HCV replication and cell transformation.
Champ scientifique
Appel à propositions
FP7-PEOPLE-2009-RG
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Régime de financement
MC-IRG - International Re-integration Grants (IRG)Coordinateur
52900 Ramat Gan
Israël