Final Report Summary - THERMOS (The protein thermostability: same activity, different working temperature. A water problem? A rigidity/flexibility trade-off?)
In conclusion, our investigation helped to clarify some molecular aspects of the stability/functionality trade-off in proteins by using thermophilic enzymes as model. Moreover, it has produced a very innovative simulation scheme to approach the proble of protein mobility and stability in vivo like condition. Finally, it has offered the possibility to our group to create inter- and cross-disciplinary collaborations that will be active well beyond the conclusion of the project.