Objective The LCAOS project will develop and test a new diagnostic tool, able to detect:(i) the presence of lung cancer (LC), and(ii) an increased risk of a patient developing LC in the future.Diagnostic tests currently available are unsuitable for widespread screening because they are costly, occasionally miss tumours, are not time-efficient, nor free of complications.LCAOS will overcome these problems by using an approach based on volatile biomarkers emitted from cell membranes. A multidisciplinary effort, incorporating nanotechnology, biomedical engineering, medical oncology, and computation strategies, will develop a highly-sensitive, inexpensive, and fast-response, non-invasive, artificial nose (known as, NaNose), building on the coordinator’s earlier success in this area. The NaNose will be able to detect pre-neoplastic volatile biomarkers that indicate an increased genetic risk of LC, and the presence of LC. It has already been established that these biomarkers can be detected either directly from the headspace of the cancer cells or via exhaled breath.LCAOS will:(i) develop arrays of chemically-sensitive field effect transistors (FETs) of non-oxidized, molecule-terminated silicon nanowires (Si NWs);(ii) test the ability of these devices to sense volatile LC biomarkers from in-vitro tissue, and exhaled human breath;(iii) study the signal transduction mechanism of the volatile biomarkers, using pattern recognition;(iv) improve systems to enable the NaNose to distinguish the targeted biomarkers from environmental clutter, using methylation, expression profiling, and genome-wide sequencing; and(v) perform clinical-related studies to assess LC conditions in actual patients & tissues, and in the presence of real-world confounding signals.Validation will be carried out by clinician partners and professional mathematicians and computer scientists. Resources will also be allocated to ensure the commercial potential of the sensor device layout. Fields of science medical and health sciencesmedical biotechnologymedical and health sciencesclinical medicineoncologylung cancerengineering and technologynanotechnologynatural sciencescomputer and information sciencesartificial intelligencepattern recognitionnatural scienceschemical sciencesinorganic chemistrymetalloids Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.1.2-1 - Tools for the identification and the detection of biomarkers in clinical samples and patients. FP7-HEALTH-2010-two-stage. Call for proposal FP7-HEALTH-2010-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Address Senate building technion city 32000 Haifa Israel See on map Activity type Higher or Secondary Education Establishments Administrative Contact Birsan Silvia (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all Ionimed Analytik GmbH Participation ended Austria EU contribution € 0,00 Address Eduard-bodem-gasse 3 6020 Innsbruck See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jens Herbig (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 577 099,95 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Sabine Koenig (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 654 457,80 Address Brownlow hill 765 foundation building L69 7ZX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Veronica Shaw (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data TEL AVIV UNIVERSITY Israel EU contribution € 473 367,18 Address Ramat aviv 69978 Tel aviv See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSIDAD COMPLUTENSE DE MADRID Spain EU contribution € 412 607,20 Address Avenida de seneca 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Administrative Contact Maribel Rodríguez Villa (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MICRONIT HOLDING BV Netherlands EU contribution € 181 185,01 Address Colosseum 15 7521 PV Enschede See on map Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marko Blom (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data JLM INNOVATION GMBH Germany EU contribution € 301 435,20 Address Beethovenweg 41 72076 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Mitrovics (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data IONICON ANALYTIK GMBH Austria EU contribution € 328 320,00 Address Eduard bodem gasse 3 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Administrative Contact Jens Herbig (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
