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A Nanoscale Artificial Nose to easily detect Volatile Biomarkers at Early stages of Lung Cancer and Related Genetic Mutations

Objective

The LCAOS project will develop and test a new diagnostic tool, able to detect:
(i) the presence of lung cancer (LC), and
(ii) an increased risk of a patient developing LC in the future.
Diagnostic tests currently available are unsuitable for widespread screening because they are costly, occasionally miss tumours, are not time-efficient, nor free of complications.
LCAOS will overcome these problems by using an approach based on volatile biomarkers emitted from cell membranes. A multidisciplinary effort, incorporating nanotechnology, biomedical engineering, medical oncology, and computation strategies, will develop a highly-sensitive, inexpensive, and fast-response, non-invasive, artificial nose (known as, NaNose), building on the coordinator’s earlier success in this area. The NaNose will be able to detect pre-neoplastic volatile biomarkers that indicate an increased genetic risk of LC, and the presence of LC. It has already been established that these biomarkers can be detected either directly from the headspace of the cancer cells or via exhaled breath.
LCAOS will:
(i) develop arrays of chemically-sensitive field effect transistors (FETs) of non-oxidized, molecule-terminated silicon nanowires (Si NWs);
(ii) test the ability of these devices to sense volatile LC biomarkers from in-vitro tissue, and exhaled human breath;
(iii) study the signal transduction mechanism of the volatile biomarkers, using pattern recognition;
(iv) improve systems to enable the NaNose to distinguish the targeted biomarkers from environmental clutter, using methylation, expression profiling, and genome-wide sequencing; and
(v) perform clinical-related studies to assess LC conditions in actual patients & tissues, and in the presence of real-world confounding signals.
Validation will be carried out by clinician partners and professional mathematicians and computer scientists. Resources will also be allocated to ensure the commercial potential of the sensor device layout.

Call for proposal

FP7-HEALTH-2010-two-stage
See other projects for this call

Coordinator

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Address
Senate Building Technion City
32000 Haifa
Israel
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 211 702,39
Administrative Contact
Birsan Silvia (Dr.)

Participants (8)

Ionimed Analytik GmbH

Participation ended

Austria
Address
Eduard-bodem-gasse 3
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jens Herbig (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 577 099,95
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Administrative Contact
Sabine Koenig (Dr.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 654 457,80
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Veronica Shaw (Ms.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 473 367,18
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 412 607,20
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maribel Rodríguez Villa (Ms.)
MICRONIT HOLDING BV
Netherlands
EU contribution
€ 181 185,01
Address
Colosseum 15
7521 PV Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marko Blom (Dr.)
JLM INNOVATION GMBH
Germany
EU contribution
€ 301 435,20
Address
Beethovenweg 41
72076 Tuebingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Mitrovics (Dr.)
IONICON ANALYTIK GMBH
Austria
EU contribution
€ 328 320
Address
Eduard Bodem Gasse 3
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jens Herbig (Dr.)