Objectif
Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innovative, rapid, and high-throughput (HTP) technologies that will translate the discovery of cancer-associated glycobiomarkers from basic science to clinical application.
The GlycoHIT consortium brings a highly experienced, innovative and interdisciplinary team of researchers from Europe, China and USA representing academia, industry and clinical fields to significantly enhance some of the existing glycoanalytical technologies and to advance novel HTP glycoanalytical technologies beyond current state of the art.
▪ Microchip technology and novel partitioning methods will be exploited for nanoscale HTP separations of serum glycoproteins for analysis by HPLC or LC–MS.
▪ In parallel, lectin array technology will be radically improved by the innovative use of recombinant human lectins and lectin mimics derived by screening large phage displayed combinatorial libraries.
▪ Aptamer libraries will be exploited for identification of lectin mimics and development of a glycosignature platform
▪ Compatibility of the lectin/lectin mimic array technologies with novel label-free biosensors will be explored.
Newly-developed technologies will be validated by analysis of serum samples from a variety of cancer patient cohorts and will be supported throughout by experimental interaction analysis, complex structural modelling and informatics.
Effective project management, commercially-aware intellectual property management and targeted dissemination activities supplement the core science and ensure maximum impact for the project.
Champ scientifique
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- natural sciencesbiological sciencesmicrobiologyvirology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesclinical medicineoncology
- natural sciencesphysical sciencesopticsspectroscopy
Appel à propositions
FP7-HEALTH-2010-single-stage
Voir d’autres projets de cet appel
Régime de financement
CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)Coordinateur
H91 Galway
Irlande
Voir sur la carte
Participants (14)
49527 PETACH TIKVA
Voir sur la carte
80539 MUNCHEN
Voir sur la carte
4 Blackrock Dublin
Voir sur la carte
17177 Stockholm
Voir sur la carte
75724 Paris
Voir sur la carte
0450 Oslo
Voir sur la carte
69120 Heidelberg
Voir sur la carte
7000 Mons
Voir sur la carte
28006 Madrid
Voir sur la carte
100084 BEIJING
Voir sur la carte
410082 CHANGSHA
Voir sur la carte
10154 New York
Voir sur la carte
A94 K542 Blackrock
Voir sur la carte
060 0808 Sapporo
Voir sur la carte