Objectif Since 2005 Chikungunya fever has affected millions of people producing a high fever and a debilitating arthralgia which can persist for months and progress to chronic arthritis. Chikungunya virus has been associated with periodic outbreaks of human disease and is spread by mosquitoes. The current epidemic rose to prominence in 2005/6 following infection of >250,000 people on La Réunion. The virus rapidly spread to other islands in the Indian Ocean, India and SE Asia. Chikungunya cases in returning travellers have been reported. In summer 2007 a traveller from India to Italy initiated a locally transmitted outbreak which included one death from encephalitis. The mosquitoes transmitting this infection are spreading and increasing in Europe and could spread as far north as the British Isles. There are diagnostics tests, these require standardisation. The pathogenic mechanisms leading to myalgia, arthralgia, rare encephalitis and chronic arthritis are unknown precluding rational therapeutic intervention. There are no antivirals. There is no licensed vaccine. This project will integrate the expertise of EU laboratories with a long and strong track record of research on alphaviruses with EU laboratories that started work on CHIKV following the outbreak in La Réunion and laboratories from SE Asia working on this virus. The project will generate new molecular and cellular tools for research and applied studies, including high-throughput screening and vaccines; standardise, quality assure and distribute key diagnostic tests and develop new ones; determine virus genetic changes across time, geographical regions and species; discover interactions between virus and human cells to inform rational design of therapeutics; study immune responses in the chronic disease in humans, including whether virus persists in joints, the cell types involved and the relationship to immune responses; characterise rodent and non-human primate models of acute and chronic infection to further study the pathogenesis and provide models for antiviral and vaccine screens; screen libraries of characterized pharmaceutical and bioactive compounds for antiviral activity and develop a vaccine which at the end of this project is ready to enter clinical trials. Champ scientifique sciences médicales et de la santémédecine cliniquerhumatologiesciences naturellessciences biologiquesmicrobiologievirologiesciences médicales et de la santémédecine fondamentaleimmunologiesciences médicales et de la santémédecine fondamentalepharmacologie et pharmacieproduit pharmaceutiquevaccinssciences médicales et de la santémédecine fondamentalepharmacologie et pharmacieproduit pharmaceutiqueantiviral Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2010.2.3.3-3 - Integrated disease-specific research on West Nile Virus infections, Chikungunya and/or Crimean Congo Haemorrhagic Fever. FP7-HEALTH-2010-single-stage Appel à propositions FP7-HEALTH-2010-single-stage Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur THE PIRBRIGHT INSTITUTE LBG Adresse Ash road pirbright GU24 0NF Woking Royaume-Uni Voir sur la carte Région South East (England) Surrey, East and West Sussex West Surrey Type d’activité Research Organisations Contact administratif Sara Hurst (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Contribution de l’UE € 364 309,85 Participants (14) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire KAROLINSKA INSTITUTET Suède Contribution de l’UE € 370 782,00 Adresse Nobels vag 5 17177 Stockholm Voir sur la carte Région Östra Sverige Stockholm Stockholms län Type d’activité Higher or Secondary Education Establishments Contact administratif Peter Liljestroem (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window TARTU ULIKOOL Estonie Contribution de l’UE € 221 774,00 Adresse Ulikooli 18 51005 Tartu Voir sur la carte Région Eesti Eesti Lõuna-Eesti Type d’activité Higher or Secondary Education Establishments Contact administratif Andres Merits (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window HELSINGIN YLIOPISTO Finlande Contribution de l’UE € 283 176,00 Adresse Yliopistonkatu 3 00014 Helsingin yliopisto Voir sur la carte Région Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Type d’activité Higher or Secondary Education Establishments Contact administratif Tero Ahola (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window INSTITUT PASTEUR France Contribution de l’UE € 107 432,00 Adresse Rue du docteur roux 25-28 75724 Paris cedex 15 Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Nadia Khelef (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window UNIVERSITE DE LA REUNION France Contribution de l’UE € 324 729,00 Adresse Avenue rene cassin 15 97715 Saint denis de la reunion cedex 9 Voir sur la carte Région Ile-de-France Ile-de-France Seine-Saint-Denis Type d’activité Higher or Secondary Education Establishments Contact administratif Philippe Gasque (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France Contribution de l’UE € 452 757,00 Adresse Rue leblanc 25 75015 Paris 15 Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Etienne Garderet (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window UNIVERSITATSKLINIKUM BONN Allemagne Contribution de l’UE € 262 440,00 Adresse Venusberg-campus 1 53127 Bonn Voir sur la carte Région Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Beate Becker (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window STEINBEIS INNOVATION GGMBH Allemagne Contribution de l’UE € 245 000,00 Adresse Adornostrasse 8 70599 Stuttgart Voir sur la carte Région Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Type d’activité Research Organisations Contact administratif Uwe Haug (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window BIOMEDICAL SCIENCES INSTITUTES Limited by Guarantee Singapour Contribution de l’UE € 10 000,00 Adresse Biopolis way 20 138668 Singapore Voir sur la carte Type d’activité Research Organisations Contact administratif Lisa F.P. Ng (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window UNIVERSITY OF MALAYA Malaisie Contribution de l’UE € 64 545,00 Adresse Lembah pantai 50603 Kuala lumpur Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Sazaly Abu Bakar (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window THE UNIVERSITY OF EDINBURGH Participation terminée Royaume-Uni Contribution de l’UE € 255 493,75 Adresse Old college, south bridge EH8 9YL Edinburgh Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Contact administratif Angela Noble (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Espagne Contribution de l’UE € 37 500,00 Adresse Calle serrano 117 28006 Madrid Voir sur la carte Région Comunidad de Madrid Comunidad de Madrid Madrid Type d’activité Research Organisations Contact administratif María ángeles López Vázquez (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window UNIVERSITY OF GLASGOW Royaume-Uni Contribution de l’UE € 0,00 Adresse University avenue G12 8QQ Glasgow Voir sur la carte Région Scotland West Central Scotland Glasgow City Type d’activité Higher or Secondary Education Establishments Contact administratif Joe Galloway (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window GRIFFITH UNIVERSITY Australie Contribution de l’UE € 0,00 Adresse Kessels road nathan 4111 Brisbane Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Kath Murrie-Jones (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window
