Objective Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know very little how microbe-host interaction triggers and regulate inflammatory cascade leading to allergic or autoimmune reaction. We propose that environmental and genetic factors, characteristic to particular disease, initiate a cascade of inflammatory events through the modulation of anti-microbial defence. The dysregulation of innate as well as adaptive immune responses leads to inappropriate responses to physical, microbial or allergen challenge, finally manifesting in the clinical symptoms of AD or PSO. We propose to use high-throughput whole microbiome and transcriptomics analysis with bioinformatics and systems biology to unravel the pathways during the host-pathogen interactions which may trigger an allergic or autoimmune reaction. We will identify key microbes and molecular targets to develop novel intervention strategies to decrease and prevent the burden of allergy and autoimmunity. Fields of science medical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineallergologynatural sciencesbiological sciencesmicrobiology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.5-2 - Infection and dysbiosis as the triggers of the development of inflammatory processes in allergies and autoimmune diseases. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator TYOTERVEYSLAITOS Address Topeliuksenkatu 41 b 00250 Helsinki Finland See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Administrative Contact Harri Alenius (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all KAROLINSKA INSTITUTET Sweden EU contribution € 1 595 979,20 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Thomas Tinglöv (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 367 779,60 Address Edmond j safra campus givat ram 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Jane Turner (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Germany EU contribution € 654 380,00 Address Universitaetsstrasse 1 40225 Dusseldorf See on map Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Martina Kuhlmann Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT CURIE France EU contribution € 590 040,00 Address Rue d ulm 26 75231 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Corinne Cumin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL Germany EU contribution € 319 156,80 Address Olshausenstrasse 40 24118 Kiel See on map Region Schleswig-Holstein Schleswig-Holstein Kiel, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Susanne Neufeldt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KING'S COLLEGE LONDON United Kingdom EU contribution € 856 468,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ICOSAGEN AS Estonia EU contribution € 324 118,80 Address Nooruse 9 50411 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Liina Marquardt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FIOS GENOMICS LIMITED United Kingdom EU contribution € 127 500,00 Address Nine edinburgh bioquarter 9 little france road EH16 4UX Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gary Rubin (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data HELSINGIN YLIOPISTO Finland EU contribution € 158 462,40 Address Yliopistonkatu 3 00014 Helsingin yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Administrative Contact Tiina Berg (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
