Skip to main content

Microbes in Allergy and Autoimmunity Related to the Skin

Objective

Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know very little how microbe-host interaction triggers and regulate inflammatory cascade leading to allergic or autoimmune reaction. We propose that environmental and genetic factors, characteristic to particular disease, initiate a cascade of inflammatory events through the modulation of anti-microbial defence. The dysregulation of innate as well as adaptive immune responses leads to inappropriate responses to physical, microbial or allergen challenge, finally manifesting in the clinical symptoms of AD or PSO. We propose to use high-throughput whole microbiome and transcriptomics analysis with bioinformatics and systems biology to unravel the pathways during the host-pathogen interactions which may trigger an allergic or autoimmune reaction. We will identify key microbes and molecular targets to develop novel intervention strategies to decrease and prevent the burden of allergy and autoimmunity.

Field of science

  • /medical and health sciences/clinical medicine/allergology
  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

TYOTERVEYSLAITOS
Address
Topeliuksenkatu 41 B
00250 Helsinki
Finland
Activity type
Research Organisations
EU contribution
€ 984 656,50
Administrative Contact
Harri Alenius (Prof.)

Participants (9)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 1 595 979,20
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Tinglöv (Mr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 367 779,60
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jane Turner (Ms.)
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 654 380
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martina Kuhlmann
INSTITUT CURIE
France
EU contribution
€ 590 040
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Administrative Contact
Corinne Cumin (Ms.)
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 319 156,80
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susanne Neufeldt (Ms.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 856 468
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
ICOSAGEN AS
Estonia
EU contribution
€ 324 118,80
Address
Nooruse 9
50411 Tartu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Liina Marquardt (Ms.)
Fios Genomics Limited
United Kingdom
EU contribution
€ 127 500
Address
Buchanan Street 166
G1 2LS Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gary Rubin (Dr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 158 462,40
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Ms.)