Obiettivo
Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know very little how microbe-host interaction triggers and regulate inflammatory cascade leading to allergic or autoimmune reaction. We propose that environmental and genetic factors, characteristic to particular disease, initiate a cascade of inflammatory events through the modulation of anti-microbial defence. The dysregulation of innate as well as adaptive immune responses leads to inappropriate responses to physical, microbial or allergen challenge, finally manifesting in the clinical symptoms of AD or PSO. We propose to use high-throughput whole microbiome and transcriptomics analysis with bioinformatics and systems biology to unravel the pathways during the host-pathogen interactions which may trigger an allergic or autoimmune reaction. We will identify key microbes and molecular targets to develop novel intervention strategies to decrease and prevent the burden of allergy and autoimmunity.
Campo scientifico
Invito a presentare proposte
FP7-HEALTH-2010-single-stage
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Meccanismo di finanziamento
CP-FP - Small or medium-scale focused research project
Coordinatore
00250 Helsinki
Finlandia
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Partecipanti (9)
17177 Stockholm
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91904 Jerusalem
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40225 Dusseldorf
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75231 Paris
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24118 Kiel
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WC2R 2LS London
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50411 Tartu
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EH16 4UX Edinburgh
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00014 Helsingin Yliopisto
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