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Infectious triggers of chronic autoimmunity

Objective

This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the induction and perpetuation of severe systemic autoimmune disease with the ultimate object of identifying new therapeutic strategies based on knowledge of pathogenesis.
Our strategy will systematically analyse the complex and diverse processes involved in a “model” human disease: - Anti-neutrophil cytoplasmic antibody (ANCA) associated systemic vasculitis (AAV). AAV is ideally suited because it is known to be caused by autoantibodies of defined specificity and second because it is strongly linked to infection to infection. INTRICATE will use mouse models to answer the specific question whether infection with clinically relevant bacteria induces autoimmune disease in transgenic mice that express the human autoantigen. The use of novel high-throughput antigen array technology in well-characterized patient cohorts and analysis of microbial and host specific mechanisms combined with genome wide association study (GWAS) will determine whether dysbiosis or infection with specific microorganisms triggers the induction or re-activation of AAV. Unraveling the pathogenic processes that are responsible for this chronic autoimmune disease and the knowledge gained will lead to the development of novel preventive and therapeutic strategies.

Call for proposal

FP7-HEALTH-2010-single-stage
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Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Address
Spitalgasse 23
1090 Wien
Austria

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dontscho Kerjaschki (Prof.)
EU contribution
€ 954 078

Participants (11)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Participation ended

Germany
EU contribution
€ 199 873,56
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Administrative Contact
Annette Starke (Ms.)
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 428 940
Address
Venusberg-campus 1
53127 Bonn

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker (Ms.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 422 740
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Kjærgaard (Mr.)
Mayo Clinic
United States
EU contribution
€ 599 849
Address
First Street Sw 200
55905 Rochester

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Activity type
Research Organisations
Administrative Contact
David E. Lynch (Mr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 766 094
Address
Hanzeplein 1
9713 GZ Groningen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Jaap Bulthuis (Mr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 523 876
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr.)
BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
United States
EU contribution
€ 522 278
Address
Serra Mall 450
94305 2004 Stanford

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marian Wu (Ms.)
EMC MICROCOLLECTIONS GMBH
Germany
EU contribution
€ 478 600
Address
Sindelfinger Str. 3
72070 Tuebingen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Renate Spohn (Dr.)
Hycult biotechnology bv
Netherlands
EU contribution
€ 178 200
Address
Frontstraat 2a
5405 PB Uden

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daisy Cooijmans (Ms.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG
Germany
EU contribution
€ 422 469
Address
Oskar Von Miller Ring 29
80333 Muenchen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 468 088,44
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

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Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)