Objective This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the induction and perpetuation of severe systemic autoimmune disease with the ultimate object of identifying new therapeutic strategies based on knowledge of pathogenesis.Our strategy will systematically analyse the complex and diverse processes involved in a “model” human disease: - Anti-neutrophil cytoplasmic antibody (ANCA) associated systemic vasculitis (AAV). AAV is ideally suited because it is known to be caused by autoantibodies of defined specificity and second because it is strongly linked to infection to infection. INTRICATE will use mouse models to answer the specific question whether infection with clinically relevant bacteria induces autoimmune disease in transgenic mice that express the human autoantigen. The use of novel high-throughput antigen array technology in well-characterized patient cohorts and analysis of microbial and host specific mechanisms combined with genome wide association study (GWAS) will determine whether dysbiosis or infection with specific microorganisms triggers the induction or re-activation of AAV. Unraveling the pathogenic processes that are responsible for this chronic autoimmune disease and the knowledge gained will lead to the development of novel preventive and therapeutic strategies. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicineimmunologyautoimmune diseasesnatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.5-2 - Infection and dysbiosis as the triggers of the development of inflammatory processes in allergies and autoimmune diseases. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MEDIZINISCHE UNIVERSITAET WIEN Address Spitalgasse 23 1090 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Dontscho Kerjaschki (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 954 078,00 Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Participation ended Germany EU contribution € 199 873,56 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Annette Starke (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITATSKLINIKUM BONN Germany EU contribution € 428 940,00 Address Venusberg-campus 1 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Becker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution € 422 740,00 Address Anker engelunds vej 101 2800 Kongens lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact Christian Kjærgaard (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Mayo Clinic United States EU contribution € 599 849,00 Address First street sw 200 55905 Rochester See on map Activity type Research Organisations Administrative Contact David E. Lynch (Mr.) Links Contact the organisation Opens in new window ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands EU contribution € 766 094,00 Address Hanzeplein 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Administrative Contact Jan Jaap Bulthuis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 523 876,00 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Keith Cann (Mr.) Links Contact the organisation Opens in new window Website Opens in new window BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY United States EU contribution € 522 278,00 Address Serra mall 450 94305 2004 Stanford See on map Activity type Higher or Secondary Education Establishments Administrative Contact Marian Wu (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EMC MICROCOLLECTIONS GMBH Germany EU contribution € 478 600,00 Address Sindelfinger str. 3 72070 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Renate Spohn (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Hycult biotechnology bv Netherlands EU contribution € 178 200,00 Address Frontstraat 2a 5405 PB Uden See on map Region Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Daisy Cooijmans (Ms.) Links Contact the organisation Opens in new window Website Opens in new window GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Germany EU contribution € 422 469,00 Address Oskar von miller ring 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Ms.) Links Contact the organisation Opens in new window Website Opens in new window HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Germany EU contribution € 468 088,44 Address Ingolstadter landstrasse 1 85764 Neuherberg See on map Region Bayern Oberbayern München, Landkreis Activity type Research Organisations Administrative Contact Juergen Ertel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
