Suicidality: Treatment Occurring in Paediatrics

Informazioni relative al progetto

STOP

ID dell’accordo di sovvenzione: 261411

Progetto chiuso

Data di avvio 1 Novembre 2010

Data di completamento 30 Aprile 2015

Finanziato da

• Specific Programme "Cooperation": Health

Costo totale € 3 748 810,72

Contributo UE € 3 000 000,00

Coordinato da

KING'S COLLEGE LONDON
United Kingdom

Obiettivo

The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Related Suicidality (PRS) in terms of phenomenology, clinical expression and time course, and may vary between children and adults. Unlike PRS, the time-course of MRS may be associated with possible differences in drug pharmacokinetics; abrupt onset; absence of suicidality prior to start of medication; and emergence of suicidality related co-morbidities after treatment.
This proposal will focus on developing a web-based comprehensive methodology for the assessment and monitoring of suicidality and its mediators in children and adolescents using the HealthTrackerTM (a paediatric web-based health outcome monitoring system), with the aim of developing a Suicidality Assessment and Monitoring Module, a Bio-psycho-social Mediators of Suicidality Assessment Module, and a Suicidality-Related Psychiatric and Physical Illness Module. The information obtained will be used to computer-generate classification of suicidality using the Classification of Suicide-Related Thoughts and Behaviour (Silverman et al, 2007) and the Columbia Classification Algorithm of Suicidal Assessment (C-CASA) (Posner et al, 2007). The existing Medication Characteristics Module will be expanded to allow documentation of pharmacological characteristics of medication, to explore whether they mediate MRS. The methodology will then be tested in 3 paediatric observational trials (risperidone in conduct disorder; fluoxetine in depression, and montelukast in bronchial asthma) and standardized, which can be used pharmacovigilance and in epidemiological, observational, and registration trials.

Campo scientifico

• medical and health sciences › clinical medicine › pneumology › asthma
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmacokinetics
• medical and health sciences › clinical medicine › paediatrics

Programma(i)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Argomento(i)

• HEALTH.2010.4.2-3 - Adverse Drug Reaction Research. FP7-HEALTH-2010-single-stage

Invito a presentare proposte

FP7-HEALTH-2010-single-stage
Vedi altri progetti per questo bando

Meccanismo di finanziamento

CP-FP - Small or medium-scale focused research project

Coordinatore

KING'S COLLEGE LONDON

• Contributo UE: € 1 119 023,19
• Indirizzo: STRAND ; WC2R 2LS London ; Regno Unito
• Regione: London › Inner London — West › Westminster
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Paul Labbett (Mr.)
• Costo totale: Nessun dato

Partecipanti (18)

STICHTING RADBOUD UNIVERSITEIT

Paesi Bassi

• Contributo UE: € 37 058,02
• Indirizzo: HOUTLAAN 4 ; 6525 XZ Nijmegen
• Regione: Oost-Nederland › Gelderland › Arnhem/Nijmegen
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Maarten Van Langen (Mr.)
• Costo totale: Nessun dato

ACADEMISCH ZIEKENHUIS GRONINGEN

Paesi Bassi

• Contributo UE: € 27 972,82
• Indirizzo: HANZEPLEIN 1 ; 9713 GZ Groningen
• Regione: Noord-Nederland › Groningen › Overig Groningen
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: J.J. Breeuwsma (Mr.)
• Costo totale: Nessun dato

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Germania

• Contributo UE: € 71 775,90
• Indirizzo: Square J 5 ; 68159 Mannheim
• Regione: Baden-Württemberg › Karlsruhe › Mannheim, Stadtkreis
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Ralf Dittmann (Prof.)
• Costo totale: Nessun dato

UNIVERSITAET ULM

Germania

• Contributo UE: € 100 294,16
• Indirizzo: HELMHOLTZSTRASSE 16 ; 89081 Ulm
• Regione: Baden-Württemberg › Tübingen › Ulm, Stadtkreis
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Frank Gleixner (Mr.)
• Costo totale: Nessun dato

UNIVERSITY OF DUNDEE

Regno Unito

• Contributo UE: € 60 231,22
• Indirizzo: Nethergate ; DD1 4HN Dundee
• Regione: Scotland › Eastern Scotland › Angus and Dundee City
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Peter Peek (Mr.)
• Costo totale: Nessun dato

THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON

Partecipazione conclusa

Regno Unito

• Contributo UE: € 85 000,00
• Indirizzo: Brunswick Square 29-39 ; WC1N 1AX LONDON
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Macey Murrey (Dr.)
• Costo totale: Nessun dato

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

Francia

• Contributo UE: € 109 900,05
• Indirizzo: 55 BOULEVARD DIDEROT ; 75012 Paris
• Regione: Ile-de-France › Ile-de-France › Val-de-Marne
• Tipo di attività: Research Organisations
• Contatto amministrativo: Christophe Misse (Mr.)
• Costo totale: Nessun dato

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.

Spagna

• Contributo UE: € 85 896,49
• Indirizzo: CALLE MONFORTE DE LEMOS 5 ; 28029 Madrid
• Regione: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Tipo di attività: Research Organisations
• Contatto amministrativo: Manuel Sanchez Delgado (Mr.)
• Costo totale: Nessun dato

FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spagna

• Contributo UE: € 184 891,12
• Indirizzo: CARRER ROSSELLO 149 ; 08036 Barcelona
• Regione: Este › Cataluña › Barcelona
• Tipo di attività: Research Organisations
• Contatto amministrativo: Sara Jane Hurst (Ms.)
• Costo totale: Nessun dato

UNIVERSITA DEGLI STUDI DI CAGLIARI

Italia

• Contributo UE: € 165 745,53
• Indirizzo: VIA UNIVERSITA 40 ; 09124 Cagliari
• Regione: Isole › Sardegna › Cagliari
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Giuseppina Tore (Ms.)
• Costo totale: Nessun dato

True Clarity Limited

Partecipazione conclusa

Regno Unito

• Contributo UE: € 143 610,00
• Indirizzo: Londonderry Farm, Keynsham Road, The Hay Barn ; BS30 6EL Willsbridge
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Andrew Davies (Mr.)
• Costo totale: Nessun dato

UNIVERSITY COLLEGE LONDON

• Contributo UE: € 113 941,00
• Indirizzo: GOWER STREET ; WC1E 6BT LONDON
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Greta Borg-Carbott (Ms.)
• Costo totale: Nessun dato

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Francia

• Contributo UE: € 41 006,00
• Indirizzo: RUE DE TOLBIAC 101 ; 75654 Paris
• Regione: Ile-de-France › Ile-de-France › Paris
• Tipo di attività: Research Organisations
• Contatto amministrativo: Annick Bertault (Ms.)
• Costo totale: Nessun dato

CONCENTRIS RESEARCH MANAGEMENT GMBH

Germania

• Contributo UE: € 300 467,54
• Indirizzo: Ludwigstr. 4 ; 82256 FURSTENFELDBRUCK
• Regione: Bayern › Oberbayern › Fürstenfeldbruck
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Ameli Schwalber (Ms.)
• Costo totale: Nessun dato

GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST

Partecipazione conclusa

Regno Unito

• Contributo UE: Nessun dato
• Indirizzo: GREAT ORMOND STREET ; WC1N 3JH London
• Regione: London › Inner London — West › Camden and City of London
• Tipo di attività: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Contatto amministrativo: Claire Newton (Ms.)
• Costo totale: Nessun dato

THE GOVERNORS OF THE UNIVERSITY OF ALBERTA

Canada

• Contributo UE: Nessun dato
• Indirizzo: 1-560 ENTERPRISE SQUARE 10230 JASPER AVENUE RESEARCH SERVICES OFFICE ; T5J 4P6 EDMONTON ALBERTA
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Julaine Herst (Ms.)
• Costo totale: Nessun dato

HEALTHTRACKER LTD

Regno Unito

• Contributo UE: € 305 420,00
• Indirizzo: Foxon Close 18 ; CR3 5SY Caterham
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Nikola Penkov (Mr.)
• Costo totale: Nessun dato

CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER

Francia

• Contributo UE: € 47 766,96
• Indirizzo: AVENUE DU DOYEN GASTON GIRAUD 191 ; 34000 Montpellier
• Regione: Occitanie › Languedoc-Roussillon › Hérault
• Tipo di attività: Research Organisations
• Contatto amministrativo: Valerie Handweiler (Mrs.)
• Costo totale: Nessun dato