Objective Autoimmunity in rheumatoid arthritis (RA) is characterised by an antibody response to citrullinated proteins. Periodontitis (PD) is largely caused by infection, in whichPorphyromonas gingivalis is a major pathogen. The two diseases combine specific HLA-DRB1alleles and smoking as risk factors, and have a similar pathophysiology characterised by destructive inflammation. A possible causative link between RA and PD is based on the ability of P. gingivalis to citrullinate proteins and thereby generate autoantigens that drive autoimmunity in RA. We hypothesise that anti-citrullinated protein antibodies can be generated, in genetically susceptible individuals, as a consequence of P. Gingivalis-induced citrullination in the gingiva. In the context of genetic risk factors, during chronic exposure to danger signals, such as bacteriallipopolysacharides and DNA, tolerance to citrullinated proteins may be broken, with production of a pathogenic antibody response, which at a later time point cross-reacts with joint proteins and causes chronic RA. We will use a multidisciplinary approach (genetics, epidemiology, molecular immunology and animal models) to study susceptibility factors and immune responses in RA and PD, with an aim to identify novel etiological and pathogenic pathways, forming the basis for new therapies. Fields of science medical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicinephysiologypathophysiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.5-2 - Infection and dysbiosis as the triggers of the development of inflammatory processes in allergies and autoimmune diseases. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITETET I BERGEN Address Museplassen 1 5020 Bergen Norway See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Administrative Contact Liv-Grethe Gudmundsen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 705 849,00 Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all Jagiellonian University in Krakow Poland EU contribution € 541 741,50 Address Ul. golebia 24 31007 Krakow See on map Region Makroregion centralny Łódzkie Miasto Łódź Activity type Higher or Secondary Education Establishments Administrative Contact Agata Potempa (Ms.) Links Contact the organisation Opens in new window Website Opens in new window KAROLINSKA INSTITUTET Sweden EU contribution € 545 993,80 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Hamilton (Ms.) Links Contact the organisation Opens in new window Website Opens in new window 4 SC AG Germany EU contribution € 703 985,60 Address Fraunhoferstr. 22 82152 Planegg martinsried See on map Region Bayern Oberbayern München, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Enno Spillner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window AARHUS UNIVERSITET Denmark EU contribution € 253 504,80 Address Nordre ringgade 1 8000 Aarhus c See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Administrative Contact Leth Stentov Pernille Links Contact the organisation Opens in new window Website Opens in new window ANAXOMICS BIOTECH SL Spain EU contribution € 160 889,20 Address Calle diputacio 237, p 1 pta 1 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vesna Radovanovic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 503 266,60 Address Calle serrano 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Eusebio Jimenez Arroyo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF BIRMINGHAM United Kingdom EU contribution € 447 759,80 Address Edgbaston B15 2TT Birmingham See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Administrative Contact Robert Fekete (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF GLASGOW United Kingdom EU contribution € 542 663,80 Address University avenue G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Administrative Contact Joe Galloway (Mr.) Links Contact the organisation Opens in new window Website Opens in new window IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Participation ended United Kingdom EU contribution € 0,00 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI FIRENZE Italy EU contribution € 433 146,70 Address Piazza san marco 4 50121 Florence See on map Region Centro (IT) Toscana Firenze Activity type Higher or Secondary Education Establishments Administrative Contact Pier Remigio Salvi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window GOETEBORGS UNIVERSITET Sweden EU contribution € 498 729,60 Address Vasaparken 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Emilia Rung (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 514 057,60 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Pialek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window
