Protein citrullination as a link between periodontal diseases and rheumatoid arthritis (RA) and target for development of novel drugs to treat RA

Informazioni relative al progetto

GUMS AND JOINTS

ID dell’accordo di sovvenzione: 261460

Progetto chiuso

Data di avvio 1 Novembre 2010

Data di completamento 31 Ottobre 2014

Finanziato da

• Specific Programme "Cooperation": Health

Costo totale € 7 588 334,62

Contributo UE € 5 851 588,00

Coordinato da

UNIVERSITETET I BERGEN
Norway

Obiettivo

Autoimmunity in rheumatoid arthritis (RA) is characterised by an antibody response to citrullinated proteins. Periodontitis (PD) is largely caused by infection, in which
Porphyromonas gingivalis is a major pathogen. The two diseases combine specific HLA-DRB1alleles and smoking as risk factors, and have a similar pathophysiology characterised by destructive inflammation. A possible causative link between RA and PD is based on the ability of P. gingivalis to citrullinate proteins and thereby generate autoantigens that drive autoimmunity in RA. We hypothesise that anti-citrullinated protein antibodies can be generated, in genetically susceptible individuals, as a consequence of P. Gingivalis-induced citrullination in the gingiva. In the context of genetic risk factors, during chronic exposure to danger signals, such as bacterial
lipopolysacharides and DNA, tolerance to citrullinated proteins may be broken, with production of a pathogenic antibody response, which at a later time point cross-reacts with joint proteins and causes chronic RA. We will use a multidisciplinary approach (genetics, epidemiology, molecular immunology and animal models) to study susceptibility factors and immune responses in RA and PD, with an aim to identify novel etiological and pathogenic pathways, forming the basis for new therapies.

Campo scientifico

• medical and health sciences › clinical medicine › rheumatology
• medical and health sciences › health sciences › public health › epidemiology
• medical and health sciences › basic medicine › physiology › pathophysiology
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › basic medicine › immunology

Programma(i)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Argomento(i)

• HEALTH.2010.2.4.5-2 - Infection and dysbiosis as the triggers of the development of inflammatory processes in allergies and autoimmune diseases. FP7-HEALTH-2010-single-stage

Invito a presentare proposte

FP7-HEALTH-2010-single-stage
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Meccanismo di finanziamento

CP-FP - Small or medium-scale focused research project

Coordinatore

UNIVERSITETET I BERGEN

Contatto amministrativo

Liv-Grethe Gudmundsen (Mr.)

• Contributo UE: € 705 849,00
• Indirizzo: MUSEPLASSEN 1 ; 5020 Bergen ; Norvegia
• Regione: Norge › Vestlandet › Vestland
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: Nessun dato

Partecipanti (12)

Jagiellonian University in Krakow

Polonia

Contatto amministrativo

Agata Potempa (Ms.)

• Contributo UE: € 541 741,50
• Indirizzo: Ul. Golebia 24 ; 31007 KRAKOW
• Regione: Makroregion centralny › Łódzkie › Miasto Łódź
• Tipo di attività: Higher or Secondary Education Establishments
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KAROLINSKA INSTITUTET

Svezia

Contatto amministrativo

Caroline Hamilton (Ms.)

• Contributo UE: € 545 993,80
• Indirizzo: Nobels Vag 5 ; 17177 Stockholm
• Regione: Östra Sverige › Stockholm › Stockholms län
• Tipo di attività: Higher or Secondary Education Establishments
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4 SC AG

Germania

Contatto amministrativo

Enno Spillner (Mr.)

• Contributo UE: € 703 985,60
• Indirizzo: FRAUNHOFERSTR. 22 ; 82152 PLANEGG MARTINSRIED
• Regione: Bayern › Oberbayern › München, Landkreis
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
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AARHUS UNIVERSITET

Danimarca

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Leth Stentov Pernille

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ANAXOMICS BIOTECH SL

Spagna

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Vesna Radovanovic (Ms.)

• Contributo UE: € 160 889,20
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AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spagna

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Eusebio Jimenez Arroyo (Mr.)

• Contributo UE: € 503 266,60
• Indirizzo: CALLE SERRANO 117 ; 28006 Madrid
• Regione: Comunidad de Madrid › Comunidad de Madrid › Madrid
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THE UNIVERSITY OF BIRMINGHAM

Regno Unito

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Robert Fekete (Mr.)

• Contributo UE: € 447 759,80
• Indirizzo: Edgbaston ; B15 2TT Birmingham
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UNIVERSITY OF GLASGOW

Regno Unito

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Joe Galloway (Mr.)

• Contributo UE: € 542 663,80
• Indirizzo: UNIVERSITY AVENUE ; G12 8QQ Glasgow
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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Partecipazione conclusa

Regno Unito

Contatto amministrativo

Tatjana Palalic (Ms.)

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• Indirizzo: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Regione: London › Inner London — West › Westminster
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UNIVERSITA DEGLI STUDI DI FIRENZE

Italia

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Pier Remigio Salvi (Prof.)

• Contributo UE: € 433 146,70
• Indirizzo: Piazza San Marco 4 ; 50121 Florence
• Regione: Centro (IT) › Toscana › Firenze
• Tipo di attività: Higher or Secondary Education Establishments
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GOETEBORGS UNIVERSITET

Svezia

Contatto amministrativo

Emilia Rung (Dr.)

• Contributo UE: € 498 729,60
• Indirizzo: VASAPARKEN ; 405 30 Goeteborg
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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Regno Unito

Contatto amministrativo

Linda Pialek (Ms.)

• Contributo UE: € 514 057,60
• Indirizzo: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford
• Regione: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
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