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Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation

Objectif

Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare diseases, particularly those of genetic origin, are associated with the requirement for solid organ transplantation as the disease progresses. At Opsona Therapeutics we have developed a novel antibody (OPN-305) which has received OMP designation (EU/3/09/638) for use in the prevention of DGF. The scientific basis of this development is the inhibition of Toll-like receptor 2 (TLR2)-mediated ischaemic reperfusion injury which has a pivotal role in the pathogenesis of DGF and its sequelae. The MABSOT project is designed to progress the development of this OMP through Phase I and II clinical trial. The successful completion of the programme will allow the continued development of OPN-305 as an OMP for the treatment of DGF in a range of solid organ transplant situations. OPN-305 development will have significant benefit to these patients and health care providers in reducing the prolonged hospitalisation of these individuals, providing greater longevity associated with the transplanted organ and enhanced quality of life for these individuals.

Appel à propositions

FP7-HEALTH-2010-single-stage
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Coordinateur

OPSONA THERAPEUTICS LIMITED
Adresse
Tara Street Ashford House 2nd Floor
2 Dublin
Irlande

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Mary Reilly (Ms.)
Contribution de l’UE
€ 2 232 195

Participants (9)

KING'S COLLEGE LONDON
United Kingdom
Contribution de l’UE
€ 1 051 131
Adresse
Strand
WC2R 2LS London

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Paul Labbett (Mr.)
EURAM LIMITED
United Kingdom
Contribution de l’UE
€ 249 187
Adresse
Lucy Tower Street Tower House
LN1 1XW Lincoln

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Andrew Banasik (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgique
Contribution de l’UE
€ 449 088
Adresse
Oude Markt 13
3000 Leuven

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Elke Lammertyn (Dr.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Participation terminée

Espagne
Adresse
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Type d’activité
Research Organisations
Contact administratif
Victoria Cochrane (Ms.)
Institut klinické a experimentální mediciny
Tchéquie
Contribution de l’UE
€ 353 271
Adresse
Videnska 1958/9
14021 Prague 4

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Type d’activité
Research Organisations
Contact administratif
Tomas Linhart (Mr.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Contribution de l’UE
€ 427 434
Adresse
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Aleona Blinova (Ms.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Pays-Bas
Contribution de l’UE
€ 443 599
Adresse
Hanzeplein 1
9713 GZ Groningen

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Johanna M Van Apeldoorn (Ms.)
ALMAC DIAGNOSTIC SERVICES LIMITED
United Kingdom
Contribution de l’UE
€ 261 511
Adresse
Seagoe Industrial Estate 20
BT63 5QD Craigavon

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Valerie Cooke (Ms.)
INSTITUT CATALA DE LA SALUT
Espagne
Contribution de l’UE
€ 461 648
Adresse
Gran Via De Les Corts Catalanes 587
08007 Barcelona

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Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contact administratif
Laia Lagunas (Ms.)