Objectif Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare diseases, particularly those of genetic origin, are associated with the requirement for solid organ transplantation as the disease progresses. At Opsona Therapeutics we have developed a novel antibody (OPN-305) which has received OMP designation (EU/3/09/638) for use in the prevention of DGF. The scientific basis of this development is the inhibition of Toll-like receptor 2 (TLR2)-mediated ischaemic reperfusion injury which has a pivotal role in the pathogenesis of DGF and its sequelae. The MABSOT project is designed to progress the development of this OMP through Phase I and II clinical trial. The successful completion of the programme will allow the continued development of OPN-305 as an OMP for the treatment of DGF in a range of solid organ transplant situations. OPN-305 development will have significant benefit to these patients and health care providers in reducing the prolonged hospitalisation of these individuals, providing greater longevity associated with the transplanted organ and enhanced quality of life for these individuals. Champ scientifique sciences médicales et de la santémédecine cliniquetransplantation Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2010.2.4.4-1 - Clinical development of substances with a clear potential as orphan drugs. FP7-HEALTH-2010-single-stage Appel à propositions FP7-HEALTH-2010-single-stage Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur OPSONA THERAPEUTICS LIMITED Adresse Tara street ashford house 2nd floor 2 Dublin Irlande Voir sur la carte Région Ireland Northern and Western Border Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Mary Reilly (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Contribution de l’UE € 2 232 195,00 Participants (9) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire KING'S COLLEGE LONDON Royaume-Uni Contribution de l’UE € 1 051 131,00 Adresse Strand WC2R 2LS London Voir sur la carte Région London Inner London — West Westminster Type d’activité Higher or Secondary Education Establishments Contact administratif Paul Labbett (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window EURAM LIMITED Royaume-Uni Contribution de l’UE € 249 187,00 Adresse Lucy tower street tower house LN1 1XW Lincoln Voir sur la carte Région East Midlands (England) Lincolnshire Lincolnshire Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Andrew Banasik (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window KATHOLIEKE UNIVERSITEIT LEUVEN Belgique Contribution de l’UE € 449 088,00 Adresse Oude markt 13 3000 Leuven Voir sur la carte Région Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Type d’activité Higher or Secondary Education Establishments Contact administratif Elke Lammertyn (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Participation terminée Espagne Contribution de l’UE € 0,00 Adresse Avenida gran via hospitalet 199-203 08908 L'hospitalet de llobregat Voir sur la carte Région Este Cataluña Barcelona Type d’activité Research Organisations Contact administratif Victoria Cochrane (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Institut klinické a experimentální mediciny Tchéquie Contribution de l’UE € 353 271,00 Adresse Videnska 1958/9 14021 Prague 4 Voir sur la carte Région Česko Praha Hlavní město Praha Type d’activité Research Organisations Contact administratif Tomas Linhart (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window UNIVERSITY OF NEWCASTLE UPON TYNE Royaume-Uni Contribution de l’UE € 427 434,00 Adresse Kings gate NE1 7RU Newcastle upon tyne Voir sur la carte Région North East (England) Northumberland and Tyne and Wear Tyneside Type d’activité Higher or Secondary Education Establishments Contact administratif Aleona Blinova (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window ACADEMISCH ZIEKENHUIS GRONINGEN Pays-Bas Contribution de l’UE € 443 599,00 Adresse Hanzeplein 1 9713 GZ Groningen Voir sur la carte Région Noord-Nederland Groningen Overig Groningen Type d’activité Higher or Secondary Education Establishments Contact administratif Johanna M Van Apeldoorn (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window ALMAC DIAGNOSTIC SERVICES LIMITED Royaume-Uni Contribution de l’UE € 261 511,00 Adresse Seagoe industrial estate 20 BT63 5QD Craigavon Voir sur la carte Région Northern Ireland Northern Ireland Armagh City Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Valerie Cooke (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window INSTITUT CATALA DE LA SALUT Espagne Contribution de l’UE € 461 648,00 Adresse Gran via de les corts catalanes 587 08007 Barcelona Voir sur la carte Région Este Cataluña Barcelona Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Laia Lagunas (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window
