Objective
Hyperlipemia and particularly, postprandial lipemia is involved in atherogenesis and is characterized by a rise of triglyceride-rich lipoproteins (TRL) after a rich fat meal. Recent studies have suggested hypolipidaemic and anti-inflammatory effects, and insulin sensitivity improvement by dietary monounsaturated fatty acids (MUFA) during the postprandial state.Vitamin B3 (nicotinic acid) has been used for treatment of dyslipidaemia associated with metabolic syndrome. Olive oil, as the main natural source of MUFA, and vitamin B3 have emerged as nutrition intervention strategies for prevention of cardiovascular disease risk at short- and long-term, respectively. Visfatin is an adipocytokine with nicotinamide phosphoribosyltransferase activity that catalyzes first step in the biosynthesis of NAD+ from nicotinamide. Extracellular visfatin converts nicotinamide into nicotinamide mononucleotide in blood, which functions as a systemic signalling molecule regulating β cell function and inflammatory responses. A regulatory role for dietary fatty acids on visfatin gene expression has been described in an in vitro model of murine adipocytes. However, there is no virtually any data about the mechanisms by which dietary fatty acids and vitamin B3, alone or in combination could regulate visfatin homeostasis in vivo, particularly in the postprandial state.
We hypothesized that different dietary fats in combination with vitamin B3 may have a key role on visfatin activity which may lead to modulation of inflammation and vascular dysfunction that are overproduced in vascular diseases. We envision achieving this through the following set of key objectives:
-To determine the influence of MUFA versus SFA or omega-3 PUFA supplemented by vitamin B3 on visfatin modulation in a human postprandial (short-term) model.
-To point out the influence of long-term dietary MUFA versus SFA or omega-3 PUFA supplemented by vitamin B3 on visfatin homeostasis in an metabolic syndrome mouse model.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences health sciences nutrition obesity
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.