Objectif In this proposal we intend to develop a new medicinal chemistry concept base on cell-personalized delivery of tailored drugs. Relying on basic chemical tools such as proximity-induced acyl transfer reactions and catalytic turnover- we will use RNA biomarkers of cancer cells to trigger the specific expression of cytotoxic drugs. This approach, in addition to contribute to basic science in chemistry and chemical and cell biology and suggest new therapeutic strategies, might allow to overcome the most important observed complications in cancer treatment: selectivity and resistance. Champ scientifique medical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencesbiological sciencescell biologymedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsRNA Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2010-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur HUMBOLDT-UNIVERSITAET ZU BERLIN Contribution de l’UE € 163 242,40 Adresse UNTER DEN LINDEN 6 10117 Berlin Allemagne Voir sur la carte Région Berlin Berlin Berlin Type d’activité Higher or Secondary Education Establishments Contact administratif Ulrich Winderl (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
