Human iPS cell therapy for spinal cord injury

Informations projet

HUMAN IPS IN SCI

N° de convention de subvention: 276130

Projet clôturé

Date de début 3 Octobre 2011

Date de fin 2 Octobre 2013

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total € 194 766,40

Contribution de l’UE € 194 766,40

Coordonné par

KAROLINSKA INSTITUTET
Suède

Objectif

Human iPS cell therapy for Spinal Cord Injury with Acronym: “Human iPS in SCI”

Our overall aim is to develop a clinically safe and effective neural cell therapy, combining novel biomaterials and human neural progenitor cells, to improve functional outcome after spinal cord injury (SCI). We have the unique possibility to compare neuro-rescue potentials of human induced pluripotent stem (iPS) cells and their neural progeny, with that of human neural precursor cells from the already formed spinal cord.

The questions raised and studied in the present research program are unique with the introduction of human iPS cells and bioresorbable hydrogels. It offers future autologous transplantation procedures and thereby no immunological and reduced ethical considerations. If we manage, we can make patient-specific cell preparations to counteract the secondary degeneration after SCI. The project is of high relevance for clinical introduction of neural cell therapy after SCI, as well as other nervous system lesions.

Our proposed project will significantly contribute and add novel and multidisciplinary competencies to my profile as research fellow, developing my skills as a valid and independent European researcher. The cultural exchange with Karolinska Institutet will allow me to gain knowledge and skills in human neural stem cell, iPS techniques, SCI in vitro and in vivo models as well as in the field of biomaterial engineering. In addition, my genuine geographical move to Karolinska Institutet, Stockholm to perform this project, offers me to join, and add knowledge to, the European research community in developing effective future cell therapies for neurodegenerative and traumatic nervous system lesions.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• sciences naturelles › sciences biologiques › neurobiologie
• sciences médicales et de la santé › biotechnologie médicale › technologies cellulaires › cellule souche
• sciences médicales et de la santé › médecine clinique › transplantation
• ingénierie et technologie › biotechnologie industrielle › biomatériaux

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Appel à propositions

FP7-PEOPLE-2010-IEF
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Régime de financement

MC-IEF -

Coordinateur

KAROLINSKA INSTITUTET

• Contribution de l’UE: € 194 766,40
• Adresse: Nobels Vag 5 ; 17177 Stockholm ; Suède
• Région: Östra Sverige › Stockholm › Stockholms län
• Type d’activité: Établissements d’enseignement supérieur ou secondaire
• Coût total: Aucune donnée