Objective
Hypertension is a major health concern because it markedly increases risk of death from stroke, atherosclerosis, and other diseases. An important environmental risk factor that contributes to the development and sustainment of hypertension is psychological stress. Given that the daily life in Western society has become increasingly stressful, a continued rise in stress-related diseases, including hypertension, is highly likely. It has become increasingly clear that inflammation and immune cell activation are fundamental to its development. In particular, T lymphocytes have been shown to play an important role in the pathophysiology of hypertension and more recently in psychological stress and depression related disabilities. Therefore, further understanding of the adaptive immune response and the underlying neuroimmune mechanism(s) in stress-related hypertension is warranted. In the proposed studies we plan to investigate the role of the adaptive immune response in stress-induced hypertension and to further characterize the underlying neurocircuitry in the brain. Using Cre-lox technology, we plan to use genetically modified mice that will allow us to specifically identify stress hormone producing cells in blood pressure control regions of the brain. In addition, we plan to delete genes such as the angiotensin II type 1a (AT1a) receptor in neurons that produce stress hormones, such as corticotropin releasing factor. These studies will provide new information for the central and peripheral mechanisms that mediate inflammatory diseases such as hypertension and may provide a better understanding for the link between the negative impact of stress on hypertension and cardiovascular disease development. The combined expertise from the host university in the pathophysiology of neurogenic hypertension and applicant’s expertise in hypertension, stress, and neuroimmunology afford us a unique opportunity to pursue this research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine neurology stroke
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BS8 1QU BRISTOL
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.