Objective
Cyclins play role in the cell division machinery and dictate the proceeding of cell cycle phases. D-type cyclins activity is required for progression through G1 phase, the critical step when cells steer the wheel to enter a new cycle of proliferation, to exit cell cycle and become quiescent or ultimately to differentiate. Generation of mice nullizygous for each of the three D-cyclin genes revealed their physiological impact as well as protective effect against cancer. Cyclin D1 is important during nervous system development, in particular for the retina and the cerebellum. However, cyclin D1 is also directly involved in the proliferative response of estrogen receptor alpha positive breast cancers and over-expressed in HER2 (ERBB2) dependent breast cancers. Recently, we reported a genome-wide function for cyclin D1 in transcriptional regulation, acting physiologically during retinal development. To affect protein production, it has been reported that transcriptional regulatory events need to be coupled with the nuclear export machinery, optimizing transfer of neo-synthesized RNAs to the cytoplasm. This suggests transcription and RNA export are spatially and temporally interconnected rather than stochastic separated phenomena. Hence, we intend to define how cyclin D1 activity governs interactions between the nuclear export and transcriptional machinery during nervous development in comparison to cancer situation. This research project relies on innovative genetics thanks to tandem tagged (Flag-HA) cyclin D1 mice model, together with modern proteomics and genomics approaches. We explore the transcriptional loop operating during cerebellum development in comparison to medulloblastoma genesis, and we extend our study to ERBB2 and ER-dependant breast cancer on the other hand. Demonstrating the mechanism of action between D-cyclins, nuclear pore complexes and transcription factors in this context, will highlight new oncogenic cell cycle components of theranostic potential.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.